About Ras-interacting protein 1
Ras-interacting protein 1 (RASIP1) is a protein
from Homo sapiens identified by UniProt accession
Q5U651, 963 residues long.
MolForge cross-references it against 0 known binders and
123 disease associations.
Target properties
| Protein name | Ras-interacting protein 1 |
|---|
| UniProt accession | Q5U651 |
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| Gene | RASIP1 |
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| Organism | Homo sapiens |
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| Length | 963 residues |
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| Molecular weight | — |
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| EC numbers | — |
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| Target class | UNCLASSIFIED |
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| Subcellular location | — |
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| Keywords | — |
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Druggability
Target tractability assessment (Open Targets + pocket analysis). No approved drug
| Druggability tier | MEDIUM |
|---|
| Druggability score | — |
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| Pocket score | — |
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| Max clinical phase | — |
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Disease associations (123)
Diseases linked to this target (Open Targets).
- neurodegenerative disease · score 0.23
- platelet count · score 0.23
- mean platelet volume · score 0.22
- systolic blood pressure · score 0.22
- serum gamma-glutamyl transferase measurement · score 0.22
- urinary metabolite measurement · score 0.21
- aspartate aminotransferase measurement · score 0.21
- diet measurement · score 0.20
- creatinine measurement · score 0.19
- BMI-adjusted waist-hip ratio · score 0.19
3D Structure (1)
Experimental (PDB) and predicted (AlphaFold) structures for this protein.
| Structure | Source | Method | Mean pLDDT | Resolution (Å) |
|---|
| AF-Q5U651-F1 | alphafold | PREDICTED | 70.66 | — |
Amino-acid sequence (963 residues)
MLSGERKEGG SPRFGKLHLP VGLWINSPRK QLAKLGRRWP SAASVKSSSS DTGSRSSEPL PPPPPHVELR RVGAVKAAGG ASGSRAKRIS QLFRGSGTGT TGSSGAGGPG TPGGAQRWAS EKKLPELAAG VAPEPPLATR ATAPPGVLKI FGAGLASGAN YKSVLATARS TARELVAEAL ERYGLAGSPG GGPGESSCVD AFALCDALGR PAAAGVGSGE WRAEHLRVLG DSERPLLVQE LWRARPGWAR RFELRGREEA RRLEQEAFGA ADSEGTGAPS WRPQKNRSRA ASGGAALASP GPGTGSGAPA GSGGKERSEN LSLRRSVSEL SLQGRRRRQQ ERRQQALSMA PGAADAQIGT ADPGDFDQLT QCLIQAPSNR PYFLLLQGYQ DAQDFVVYVM TREQHVFGRG GNSSGRGGSP APYVDTFLNA PDILPRHCTV RAGPEHPAMV RPSRGAPVTH NGCLLLREAE LHPGDLLGLG EHFLFMYKDP RTGGSGPARP PWLPARPGAT PPGPGWAFSC RLCGRGLQER GEALAAYLDG REPVLRFRPR EEEALLGEIV RAAAAGSGDL PPLGPATLLA LCVQHSAREL ELGHLPRLLG RLARLIKEAV WEKIKEIGDR QPENHPEGVP EVPLTPEAVS VELRPLMLWM ANTTELLSFV QEKVLEMEKE ADQEDPQLCN DLELCDEAMA LLDEVIMCTF QQSVYYLTKT LYSTLPALLD SNPFTAGAEL PGPGAELGAM PPGLRPTLGV FQAALELTSQ CELHPDLVSQ TFGYLFFFSN ASLLNSLMER GQGRPFYQWS RAVQIRTNLD LVLDWLQGAG LGDIATEFFR KLSMAVNLLC VPRTSLLKAS WSSLRTDHPT LTPAQLHHLL SHYQLGPGRG PPAAWDPPPA EREAVDTGDI FESFSSHPPL ILPLGSSRLR LTGPVTDDAL HRELRRLRRL LWDLEQQELP ANYRHGPPVA TSP
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