About Arf-GAP with GTPase, ANK repeat and PH domain-containing protein 9
Arf-GAP with GTPase, ANK repeat and PH domain-containing protein 9 (AGAP9) is a protein
from Homo sapiens identified by UniProt accession
Q5VTM2, 703 residues long.
MolForge cross-references it against 0 known binders and
33 disease associations.
Target properties
| Protein name | Arf-GAP with GTPase, ANK repeat and PH domain-containing protein 9 |
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| UniProt accession | Q5VTM2 |
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| Gene | AGAP9 |
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| Organism | Homo sapiens |
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| Length | 703 residues |
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| Molecular weight | — |
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| EC numbers | — |
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| Target class | UNCLASSIFIED |
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| Subcellular location | — |
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| Keywords | — |
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Druggability
Target tractability assessment (Open Targets + pocket analysis). No approved drug
| Druggability tier | MEDIUM |
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| Druggability score | — |
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| Pocket score | — |
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| Max clinical phase | — |
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Disease associations (33)
Diseases linked to this target (Open Targets).
- deaf blind hypopigmentation syndrome, Yemenite type · score 0.05
- Cataract-microcornea syndrome · score 0.04
- otodental syndrome · score 0.04
- Familial ocular anterior segment mesenchymal dysgenesis · score 0.04
- uveal coloboma-cleft lip and palate-intellectual disability · score 0.04
- colorectal adenocarcinoma · score 0.04
- Megalocornea · score 0.04
- megalocornea · score 0.04
- Axenfeld-Rieger syndrome type 1 · score 0.03
- congenital primary aphakia · score 0.03
3D Structure (1)
Experimental (PDB) and predicted (AlphaFold) structures for this protein.
| Structure | Source | Method | Mean pLDDT | Resolution (Å) |
|---|
| AF-Q5VTM2-F1 | alphafold | PREDICTED | 62.23 | — |
Amino-acid sequence (703 residues)
MFEDVFSDSG NTGNFDRGKK RRLTIIECGC DINMMIDLAK VADLVLMLID ASFGFEMEMF EFLNICQAHG FPKILGVLTH LDSFKHNKQL KKTKKRLKHR FWTEVYQDKV GLTHELVQSL ISTYSTIDAK MASSRVTLLS NSKPLGSEAI DNQGVSLEFD QQQGSVCPSE SEIYEAGAED RMAGAPMAAA VQPAEVTVEV GEDLHMHQVR DREMPEVVEI RRSNCTNHCD LGDTSSYHTK VSTVHIMKKR NGGGSLNNYS SSIPPTPSTS QEDPQFSVPP TANTPTPVCK RSMRWSNLFT SEKGSDPDKE RKAPENHADT IGSGRAIPIK QGMLLKRSGK WLKTWKKKYV TLCSNGVLTY YSSLGDYMKN IHKKEIDLRT STIKVPGKWP SLATSACAPI SSSKSNGLSK DMDTGLGDSI CFSPGISSTT SPKLNPPPSP HANKKKHLKK KSTNNFMIVS ATGQTWHFEA TTYEERDAWV QAIQSQILAS LQSCKSSKSK SQLTSQSEAM ALQSIQNMRG NAHCVDCETQ NPKWASLNLG VLMCIECSGI HRSFGTRLSR VRSLELDDWP VELRKVMSSI GNELANSIWE GSSQGQTKPS IKSTREEKEW WIRSKYEEKL FLAPLPCTEL SLGQQLLRAT TDEDLQTAIL LLAHGSREEV NETCGEGDGC TALHLACRKG NVVLEQLLTG WTSWPEMPTG TQR
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