About Tetratricopeptide repeat protein 39B
Tetratricopeptide repeat protein 39B (TTC39B) is a protein
from Homo sapiens identified by UniProt accession
Q5VTQ0, 682 residues long.
MolForge cross-references it against 0 known binders and
65 disease associations.
Target properties
| Protein name | Tetratricopeptide repeat protein 39B |
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| UniProt accession | Q5VTQ0 |
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| Gene | TTC39B |
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| Organism | Homo sapiens |
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| Length | 682 residues |
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| Molecular weight | — |
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| EC numbers | — |
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| Target class | UNCLASSIFIED |
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| Subcellular location | — |
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| Keywords | — |
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Druggability
Target tractability assessment (Open Targets + pocket analysis). No approved drug
| Druggability tier | MEDIUM |
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| Druggability score | — |
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| Pocket score | — |
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| Max clinical phase | — |
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Disease associations (65)
Diseases linked to this target (Open Targets).
- high density lipoprotein cholesterol measurement · score 0.53
- cholelithiasis · score 0.48
- total cholesterol measurement · score 0.47
- apolipoprotein A 1 measurement · score 0.46
- apolipoprotein B measurement · score 0.43
- gallstones · score 0.43
- triglyceride measurement · score 0.42
- macular telangiectasia type 2 · score 0.40
- alcohol consumption measurement · score 0.40
- alcohol drinking · score 0.40
3D Structure (1)
Experimental (PDB) and predicted (AlphaFold) structures for this protein.
| Structure | Source | Method | Mean pLDDT | Resolution (Å) |
|---|
| AF-Q5VTQ0-F1 | alphafold | PREDICTED | 80.87 | — |
Amino-acid sequence (682 residues)
MDAVLACRLR GRGNRVAALR PRPRPGGSAG PSPFALLCAG LSPEPRAGVG SEFPAWFLGG SSQRRNMALL GSRAELEADE DVFEDALETI SISSHSDMAT SSLHFASCDT QQAPRQRGAS TVSSSSSTKV DLKSGLEECA VALNLFLSNK FTDALELLRP WAKESMYHAL GYSTIVVLQA VLTFEQQDIQ NGISAMKDAL QTCQKYRKKY TVVESFSSLL SRGSLEQLSE EEMHAEICYA ECLLQKAALT FVQDENMINF IKGGLKIRTS YQIYKECLSI LHEIQKNKLQ QEFFYEFEGG VKLGSGAFNL MLSLLPARII RLLEFIGFSG NRELGLLQLR EGASGRSMRS ALCCLTILAF HTYISLILGT GEVNVAEAER LLAPFLQQFP NGSLVLFYHA RIELLKGNLE EAQEVFQKCI SVQEEWKQFH HLCYWELMWI NVFQQNWMQA YYYSDLLCKE SKWSKATYVF LKAAILSMLP EEDVVATNEN VVTLFRQVDS LKQRIAGKSI PTEKFAVRKA RRYSASLPAP VKLILPALEM MYVWNGFSIV SKRKDLSENL LVTVEKAEAA LQSQNFNSFS VDDECLVKLL KGCCLKNLQR PLQAELCYNH VVESEKLLKY DHYLVPFTLF ELASLYKSQG EIDKAIKFLE TARNNYKDYS LESRLHFRIQ AALHLWRKPS SD
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