About Arf-GAP with GTPase, ANK repeat and PH domain-containing protein 6
Arf-GAP with GTPase, ANK repeat and PH domain-containing protein 6 (AGAP6) is a protein
from Homo sapiens identified by UniProt accession
Q5VW22, 663 residues long.
MolForge cross-references it against 0 known binders and
10 disease associations.
Target properties
| Protein name | Arf-GAP with GTPase, ANK repeat and PH domain-containing protein 6 |
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| UniProt accession | Q5VW22 |
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| Gene | AGAP6 |
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| Organism | Homo sapiens |
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| Length | 663 residues |
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| Molecular weight | — |
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| EC numbers | — |
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| Target class | UNCLASSIFIED |
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| Subcellular location | — |
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| Keywords | — |
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Druggability
Target tractability assessment (Open Targets + pocket analysis). No approved drug
| Druggability tier | MEDIUM |
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| Druggability score | — |
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| Pocket score | — |
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| Max clinical phase | — |
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Disease associations (10)
Diseases linked to this target (Open Targets).
- mean reticulocyte volume · score 0.28
- glomerular filtration rate · score 0.17
- wellbeing measurement · score 0.13
- alcohol consumption measurement · score 0.13
- injury · score 0.06
- self reported educational attainment · score 0.03
- prostate carcinoma · score 0.00
- cholangiocarcinoma · score 0.00
- Rett syndrome · score 0.00
- cancer · score 0.00
3D Structure (1)
Experimental (PDB) and predicted (AlphaFold) structures for this protein.
| Structure | Source | Method | Mean pLDDT | Resolution (Å) |
|---|
| AF-Q5VW22-F1 | alphafold | PREDICTED | 63.28 | — |
Amino-acid sequence (663 residues)
MGNILTCRVH PSVSLEFDQQ QGSVCPSESE TYEAGARDRM AGAPMAAAVQ PAEVTVEVGE DLHMHHVRDR EMPEALEFNP SANPEASTIF QRNSQTDVVE IRRSNCTNHV SAVRFSQQYS LCSTIFLDDS TAIQHYLTMT IISVTLEIPH HITQRDADRT LSIPDEQLHS FAVSTVHIMK KRNGGGSLNN YSSSIPSTPS TSQEDPQFSV PPTANTPTPV CKRSMRWSNL FTSEKGSDPD KERKAPENHA DTIGSGRAIP IKQGMLLKRS GKWLKTWKKK YVTLCSNGML TYYSSLGDYM KNIHKKEIDL QTSTIKVPGK WPSLATSACT PISSSKSNGL SKDMDTGLGD SICFSPSISS TTSPKLNPPP SPHANKKKHL KKKSTNNFMI VSATGQTWHF EATTYEERDA WVQAIQSQIL ASLQSCESSK SKSQLTSQSE AMALQSIQNM RGNAHCVDCE TQNPKWASLN LGVLMCIECS GIHRSLGPHL SRVRSLELDD WPVELRKVMS SIVNDLANSI WEGSSQGQTK PSEKSTREEK ERWIRSKYEE KLFLAPLPCT ELSLGQQLLR ATADEDLQTA ILLLAHGSCE EVNETCGEGD GCTALHLACR KGNVVLAQLL IWYGVDVMAR DAHGNTALTY ARQASSQECI NVLLQYGCPD ECV
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