About Very-long-chain (3R)-3-hydroxyacyl-CoA dehydratase 4
Very-long-chain (3R)-3-hydroxyacyl-CoA dehydratase 4 (HACD4) is a protein
from Homo sapiens identified by UniProt accession
Q5VWC8, 232 residues long.
MolForge cross-references it against 0 known binders and
35 disease associations.
Target properties
| Protein name | Very-long-chain (3R)-3-hydroxyacyl-CoA dehydratase 4 |
|---|
| UniProt accession | Q5VWC8 |
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| Gene | HACD4 |
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| Organism | Homo sapiens |
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| Length | 232 residues |
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| Molecular weight | — |
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| EC numbers | — |
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| Target class | UNCLASSIFIED |
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| Subcellular location | — |
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| Keywords | — |
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Druggability
Target tractability assessment (Open Targets + pocket analysis). No approved drug
| Druggability tier | MEDIUM |
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| Druggability score | — |
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| Pocket score | — |
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| Max clinical phase | — |
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Disease associations (35)
Diseases linked to this target (Open Targets).
- cytokine measurement · score 0.36
- erythrocyte count · score 0.16
- daytime rest measurement · score 0.13
- type 2 diabetes mellitus · score 0.09
- lymphocyte count · score 0.09
- red blood cell density measurement · score 0.09
- mean corpuscular volume · score 0.09
- mean corpuscular hemoglobin · score 0.08
- mean corpuscular hemoglobin concentration · score 0.06
- platelet crit · score 0.05
3D Structure (1)
Experimental (PDB) and predicted (AlphaFold) structures for this protein.
| Structure | Source | Method | Mean pLDDT | Resolution (Å) |
|---|
| AF-Q5VWC8-F1 | alphafold | PREDICTED | 85.51 | — |
Amino-acid sequence (232 residues)
MGPLALPAWL QPRYRKNAYL FIYYLIQFCG HSWIFTNMTV RFFSFGKDSM VDTFYAIGLV MRLCQSVSLL ELLHIYVGIE SNHLLPRFLQ LTERIIILFV VITSQEEVQE KYVVCVLFVF WNLLDMVRYT YSMLSVIGIS YAVLTWLSQT LWMPIYPLCV LAEAFAIYQS LPYFESFGTY STKLPFDLSI YFPYVLKIYL MMLFIGMYFT YSHLYSERRD ILGIFPIKKK KM
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