Terminal nucleotidyltransferase 5C (TENT5C)

About Terminal nucleotidyltransferase 5C

Terminal nucleotidyltransferase 5C (TENT5C) is a protein from Homo sapiens identified by UniProt accession Q5VWP2, 391 residues long. MolForge cross-references it against 0 known binders and 349 disease associations.

Target properties

Protein name	Terminal nucleotidyltransferase 5C
UniProt accession	Q5VWP2
Gene	TENT5C
Organism	Homo sapiens
Length	391 residues
Molecular weight	—
EC numbers	—
Target class	UNCLASSIFIED
Subcellular location	—
Keywords	—

Druggability

Target tractability assessment (Open Targets + pocket analysis). No approved drug

Druggability tier	MEDIUM
Druggability score	—
Pocket score	—
Max clinical phase	—

Disease associations (349)

Diseases linked to this target (Open Targets).

reticulocyte count · score 0.65
reticulocyte measurement · score 0.63
mean corpuscular volume · score 0.59
mean corpuscular hemoglobin · score 0.59
multiple myeloma · score 0.57
mean corpuscular hemoglobin concentration · score 0.54
Red cell distribution width · score 0.48
platelet count · score 0.47
mean platelet volume · score 0.47
erythrocyte count · score 0.47

3D Structure (1)

Experimental (PDB) and predicted (AlphaFold) structures for this protein.

Structure	Source	Method	Mean pLDDT	Resolution (Å)
AF-Q5VWP2-F1	alphafold	PREDICTED	87.24	—

Amino-acid sequence (391 residues)

MAEESSCTRD CMSFSVLNWD QVSRLHEVLT EVVPIHGRGN FPTLEITLKD IVQTVRSRLE EAGIKVHDVR LNGSAAGHVL VKDNGLGCKD LDLIFHVALP TEAEFQLVRD VVLCSLLNFL PEGVNKLKIS PVTLKEAYVQ KLVKVCTDTD RWSLISLSNK NGKNVELKFV DSIRRQFEFS VDSFQIILDS LLFFYDCSNN PISEHFHPTV IGESMYGDFE EAFDHLQNRL IATKNPEEIR GGGLLKYSNL LVRDFRPTDQ EEIKTLERYM CSRFFIDFPD ILEQQRKLET YLQNHFAEEE RSKYDYLMIL RRVVNESTVC LMGHERRQTL NLISLLALRV LAEQNIIPSA TNVTCYYQPA PYVSDGNFSN YYVAHPPVTY SQPYPTWLPC N

External references

UniProt AlphaFold QuickGO RCSB PDB GeneCards