About Muscular LMNA-interacting protein
Muscular LMNA-interacting protein (MLIP) is a protein
from Homo sapiens identified by UniProt accession
Q5VWP3, 993 residues long.
MolForge cross-references it against 0 known binders and
92 disease associations.
Target properties
| Protein name | Muscular LMNA-interacting protein |
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| UniProt accession | Q5VWP3 |
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| Gene | MLIP |
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| Organism | Homo sapiens |
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| Length | 993 residues |
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| Molecular weight | — |
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| EC numbers | — |
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| Target class | UNCLASSIFIED |
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| Subcellular location | — |
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| Keywords | — |
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Druggability
Target tractability assessment (Open Targets + pocket analysis). No approved drug
| Druggability tier | MEDIUM |
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| Druggability score | — |
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| Pocket score | — |
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| Max clinical phase | — |
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Disease associations (92)
Diseases linked to this target (Open Targets).
- myopathy with myalgia, increased serum creatine kinase, and with or without episodic rhabdomyolysis · score 0.68
- serum gamma-glutamyl transferase measurement · score 0.50
- serum alanine aminotransferase measurement · score 0.47
- alkaline phosphatase measurement · score 0.46
- lean body mass · score 0.43
- pulse pressure measurement · score 0.42
- body mass index · score 0.40
- serum albumin measurement · score 0.33
- body weight · score 0.33
- aspartate aminotransferase to alanine aminotransferase ratio · score 0.33
3D Structure (1)
Experimental (PDB) and predicted (AlphaFold) structures for this protein.
| Structure | Source | Method | Mean pLDDT | Resolution (Å) |
|---|
| AF-Q5VWP3-F1 | alphafold | PREDICTED | 43.33 | — |
Amino-acid sequence (993 residues)
MLSEQGLLSD CGNNYFQMTS CILSGSIQTT PQVSAGGSEA KPLIFTFVPT VRRLPTHTQL ADTSKFLVKI PEESSDKSPE TVNRSKSNDY LTLNAGSQQE RDQAKLTCPS EVSGTILQER EFEANKLQGM QQSDLFKAEY VLIVDSEGED EAASRKVEQG PPGGIGTAAV RPKSLAISSS LVSDVVRPKT QGTDLKTSSH PEMLHGMAPQ QKHGQLTSSP TTSEQLACKP PAFSFVSPTN PNTPPDPVNL EGASVLEEFH TRRLDVGGAV VEESATYFQT TAHSTPFSAS KGTSSTLLFP HSTQLSGSNL PSSTAADPKP GLTSEVLKKT TLTSHVLSHG ESPRTSSSPP SSSASLKSNS ASYIPVRIVT HSLSPSPKPF TSSFHGSSST ICSQMSSSGN LSKSGVKSPV PSRLALLTAI LKSNPSHQRP FSPASCPTFS LNSPASSTLT LDQKEKQTPP TPKKSLSSCS LRAGSPDQGE LQVSELTQQS FHLPVFTKST PLSQAPSLSP TKQASSSLAS MNVERTPSPT LKSNTMLSLL QTSTSSSVGL PPVPPSSSLS SLKSKQDGDL RGPENPRNIH TYPSTLASSA LSSLSPPINQ RATFSSSEKC FHPSPALSSL INRSKRASSQ LSGQELNPSA LPSLPVSSAD FASLPNLRSS SLPHANLPTL VPQLSPSALH PHCGSGTLPS RLGKSESTTP NHRSPVSTPS LPISLTRTEE LISPCALSMS TGPENKKSKQ YKTKSSYKAF AAIPTNTLLL EQKALDEPAK TESVSKDNTL EPPVELYFPA QLRQQTEELC ATIDKVLQDS LSMHSSDSPS RSPKTLLGSD TVKTPTTLPR AAGRETKYAN LSSPSSTVSE SQLTKPGVIR PVPVKSRILL KKEEEVYEPN PFSKYLEDNS DLFSEQDVTV PPKPVSLHPL YQTKLYPPAK SLLHPQTLSH ADCLAPGPFS HLSFSLSDEQ ENSHTLLSHN ACNKLSHPMV AIPEHEALDS KEQ
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