About Synaptophysin-like protein 2
Synaptophysin-like protein 2 (SYPL2) is a protein
from Homo sapiens identified by UniProt accession
Q5VXT5, 272 residues long.
MolForge cross-references it against 0 known binders and
133 disease associations.
Target properties
| Protein name | Synaptophysin-like protein 2 |
|---|
| UniProt accession | Q5VXT5 |
|---|
| Gene | SYPL2 |
|---|
| Organism | Homo sapiens |
|---|
| Length | 272 residues |
|---|
| Molecular weight | — |
|---|
| EC numbers | — |
|---|
| Target class | UNCLASSIFIED |
|---|
| Subcellular location | — |
|---|
| Keywords | — |
|---|
Druggability
Target tractability assessment (Open Targets + pocket analysis). No approved drug
| Druggability tier | MEDIUM |
|---|
| Druggability score | — |
|---|
| Pocket score | — |
|---|
| Max clinical phase | — |
|---|
Disease associations (133)
Diseases linked to this target (Open Targets).
- cognitive function measurement · score 0.17
- intelligence · score 0.17
- self reported educational attainment · score 0.17
- sortilin measurement · score 0.17
- glomerular filtration rate · score 0.15
- PR interval · score 0.14
- apolipoprotein B measurement · score 0.13
- chronotype measurement · score 0.13
- body mass index · score 0.11
- creatinine measurement · score 0.10
3D Structure (1)
Experimental (PDB) and predicted (AlphaFold) structures for this protein.
| Structure | Source | Method | Mean pLDDT | Resolution (Å) |
|---|
| AF-Q5VXT5-F1 | alphafold | PREDICTED | 80.76 | — |
Amino-acid sequence (272 residues)
MSSTESAGRT ADKSPRQQVD RLLVGLRWRR LEEPLGFIKV LQWLFAIFAF GSCGSYSGET GAMVRCNNEA KDVSSIIVAF GYPFRLHRIQ YEMPLCDEES SSKTMHLMGD FSAPAEFFVT LGIFSFFYTM AALVIYLRFH NLYTENKRFP LVDFCVTVSF TFFWLVAAAA WGKGLTDVKG ATRPSSLTAA MSVCHGEEAV CSAGATPSMG LANISVLFGF INFFLWAGNC WFVFKETPWH GQGQGQDQDQ DQDQGQGPSQ ESAAEQGAVE KQ
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