Immediate early response gene 5 protein (IER5)

About Immediate early response gene 5 protein

Immediate early response gene 5 protein (IER5) is a protein from Homo sapiens identified by UniProt accession Q5VY09, 327 residues long. MolForge cross-references it against 0 known binders and 64 disease associations.

Target properties

Protein name	Immediate early response gene 5 protein
UniProt accession	Q5VY09
Gene	IER5
Organism	Homo sapiens
Length	327 residues
Molecular weight	—
EC numbers	—
Target class	UNCLASSIFIED
Subcellular location	—
Keywords	—

Druggability

Target tractability assessment (Open Targets + pocket analysis). No approved drug

Druggability tier	MEDIUM
Druggability score	—
Pocket score	—
Max clinical phase	—

Disease associations (64)

Diseases linked to this target (Open Targets).

eosinophil count · score 0.41
neuroimaging measurement · score 0.33
neurodegenerative disease · score 0.31
eosinophil percentage of leukocytes · score 0.27
brain measurement · score 0.26
cortical thickness · score 0.26
gut microbiome measurement · score 0.23
monocyte percentage of leukocytes · score 0.19
cancer · score 0.08
acute myeloid leukemia · score 0.08

3D Structure (1)

Experimental (PDB) and predicted (AlphaFold) structures for this protein.

Structure	Source	Method	Mean pLDDT	Resolution (Å)
AF-Q5VY09-F1	alphafold	PREDICTED	53.55	—

Amino-acid sequence (327 residues)

MEFKLEAHRI VSISLGKIYN SRVQRGGIKL HKNLLVSLVL RSARQVYLSD PCPGLYLAGP AGTPAPPPQQ QPGEPAAGPP AGWGEPPPPA ARASWPETEP QPERSSVSDA PRVGDEVPVA TVTGVGDVFQ GGEADATEAA WSRVEGPRQA AAREAEGTAG GWGVFPEVSR AARRPCGCPL GGEDPPGTPA ATPRAACCCA PQPAEDEPPA PPAVCPRKRC AAGVGGGPAG CPAPGSTPLK KPRRNLEQPP SGGEDDDAEE METGNVANLI SIFGSSFSGL LRKSPGGGRE EEEGEESGPE AAEPGQICCD KPVLRDMNPW STAIVAF

External references

UniProt AlphaFold QuickGO RCSB PDB GeneCards