About SH2 domain-containing adapter protein E
SH2 domain-containing adapter protein E (SHE) is a protein
from Homo sapiens identified by UniProt accession
Q5VZ18, 495 residues long.
MolForge cross-references it against 0 known binders and
55 disease associations.
Target properties
| Protein name | SH2 domain-containing adapter protein E |
|---|
| UniProt accession | Q5VZ18 |
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| Gene | SHE |
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| Organism | Homo sapiens |
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| Length | 495 residues |
|---|
| Molecular weight | — |
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| EC numbers | — |
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| Target class | UNCLASSIFIED |
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| Subcellular location | — |
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| Keywords | — |
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Druggability
Target tractability assessment (Open Targets + pocket analysis). No approved drug
| Druggability tier | MEDIUM |
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| Druggability score | — |
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| Pocket score | — |
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| Max clinical phase | — |
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Disease associations (55)
Diseases linked to this target (Open Targets).
- neurodegenerative disease · score 0.39
- C-reactive protein measurement · score 0.13
- interleukin 6 receptor subunit alpha measurement · score 0.12
- leukocyte count · score 0.11
- blood protein measurement · score 0.11
- coronary artery disease · score 0.11
- interleukin-6 measurement · score 0.09
- Red cell distribution width · score 0.09
- mean platelet volume · score 0.08
- alkaline phosphatase measurement · score 0.08
3D Structure (1)
Experimental (PDB) and predicted (AlphaFold) structures for this protein.
| Structure | Source | Method | Mean pLDDT | Resolution (Å) |
|---|
| AF-Q5VZ18-F1 | alphafold | PREDICTED | 59.02 | — |
Amino-acid sequence (495 residues)
MQWSPTPGAS ACLGWASSLA CSTAPTLLGR AGRGPLMAAK WFKEFPLNLK TVSERAKPGG GGGKLRKNSE AGGAGPGPGK GRKNSAAELG SGRAGVGPKD SRLSRDSLQG LIQAAAGKGR KNSRATEEEP HRGATKSSGC STYINRLIKV DTQEKNGKSN YPSSSSSSSS SSSSASSSPS SLGPELDKGK IIKQQETVII LEDYADPYDA KRTKGQRDAE RVGENDGYME PYDAQQMITE IRRRGSKDPL VKALQLLDSP CEPADGGLKS ETLAKRRSSK DLLGKPPQLY DTPYEPAEGG PRAEGKARPP DSRLPENDER PAAEYEQPWE WKKEQIVRAL SVQFEGAERP SFREETVRQH HRQKSWTQKI LKPALSDHSE GEKVDPGLPL EKQPWYHGAI SRAEAESRLQ PCKEAGYLVR NSESGNSRYS IALKTSQGCV HIIVAQTKDN KYTLNQTSAV FDSIPEVVHY YSNEKLPFKG AEHMTLLYPV HSKLH
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