About DENN domain-containing protein 4C
DENN domain-containing protein 4C (DENND4C) is a protein
from Homo sapiens identified by UniProt accession
Q5VZ89, 1909 residues long.
MolForge cross-references it against 0 known binders and
21 disease associations.
Target properties
| Protein name | DENN domain-containing protein 4C |
|---|
| UniProt accession | Q5VZ89 |
|---|
| Gene | DENND4C |
|---|
| Organism | Homo sapiens |
|---|
| Length | 1909 residues |
|---|
| Molecular weight | — |
|---|
| EC numbers | — |
|---|
| Target class | UNCLASSIFIED |
|---|
| Subcellular location | — |
|---|
| Keywords | — |
|---|
Druggability
Target tractability assessment (Open Targets + pocket analysis). No approved drug
| Druggability tier | MEDIUM |
|---|
| Druggability score | — |
|---|
| Pocket score | — |
|---|
| Max clinical phase | — |
|---|
Disease associations (21)
Diseases linked to this target (Open Targets).
- neurodegenerative disease · score 0.33
- low density lipoprotein cholesterol measurement · score 0.33
- mean corpuscular volume · score 0.32
- mean corpuscular hemoglobin concentration · score 0.31
- HMG CoA reductase inhibitor use measurement · score 0.31
- sleep apnea measurement · score 0.28
- Hypercholesterolemia · score 0.27
- Red cell distribution width · score 0.26
- cardiovascular disease · score 0.26
- mean corpuscular hemoglobin · score 0.26
3D Structure (1)
Experimental (PDB) and predicted (AlphaFold) structures for this protein.
| Structure | Source | Method | Mean pLDDT | Resolution (Å) |
|---|
| AF-Q5VZ89-F1 | alphafold | PREDICTED | 63.98 | — |
Amino-acid sequence (1909 residues)
MIEDKGPRVT DYFVVAGLTD TSTLLDQEIN RLDTKSTGPK APITDIAIII KSAGETVPEG YTCVEATPSA LQANLNYGSL KSPELFLCYK RGRDKPPLTD IGVLYEGKER LIPGCEVILA TPYGRCANVN NSSTTSQRIF ITYRRAPPVR PQNSLAVTDI CVIVTSKGET PPHTFCKVDK NLNCGMWGSS VFLCYKKSVP ASNAIAYKAG LIFRYPEEDY ESFPLSESDV PLFCLPMGAT IECWDPETKY PLPVFSTFVL TGSSAKKVYG AAIQFYEPYS RELLSEKQLM HLGLLTPVER KMVSKSINTN KCICLLSHWP FFEAFRKFLM FIYKLSVSGP HPLPIEKHIS HFMQNIPFPS PQRPRILVQL SVHDALILSQ PVSTPLPLSG ANFSTLLMNL GPENCATLLL FVLLESKILL HSLRPAVLTG VAEAVVAMIF PFQWQCPYIP LCPLSLAAVL SAPLPFIVGV DSRYFDLHDP PQDVVCIDLD TNMLYVSDEK KNMNWKQLPK KPCKNLLSTL KKLYPQLSSV HQKTQEGSAI DMTPIEADFS WQKKMTQLEM EIQEAFLRFM ASILKGYRTY LRPITEAPSN KATAADSLFD RQGFLKSRDR AYAKFYTLLS KTQIFIRFIE ECSFVSDKDT GLAFFDDCIE KLFPDKGTEK TDKVDFDSAE DTRLIELDDS QKSEHTVFIM PPEPPPDDGK DLSPKYSYKY FPRLDLKLFD RPQELKLCFS RHPTGNSITK SPPLMAKRTK QEIKTAHKLA KRCYTNPPQW AKCLFSHCYS LWFICLPAYV RVSHPKVRAL QQAYDVLIKM RKTDVDPLDE VCYRVVMQLC GLWGHPVLAV RVLFEMKTAR IKPNAITYGY YNKVVLESPW PSSTRSGIFL WTKVRNVVRG LAQFRQPLKK TVQRSQVSSI SGGQSDQGYG SKDELIKDDA EIHVPEEQAA RELITKTKMQ TEEVCDASAI VAKHSQPSPE PHSPTEPPAW GSSIVKVPSG IFDVNSRKSS TGSISNVLFS TQDPVEDAVF GEATNLKKNG DRGEKRQKHF PERSCSFSSE SRAGMLLKKS SLDSNSSEMA IMMGADAKIL TAALTCPKTS LLHIARTHSF ENVSCHLPDS RTCMSESTWN PEHRSSPVPE MLEESQELLE PVVDDVPKTT ATVDTYESLL SDSNSNQSRD LKTVSKDLRN KRSSLYGIAK VVQREDVETG LDPLSLLATE CTGGKTPDSE DKLFSPVIAR NLADEIESYM NLKSPLGSKS SSMELHREEN RESGMTTAFI HALERRSSLP LDHGSPAQEN PESEKSSPAV SRSKTFTGRF KQQTPSRTHK ERSTSLSALV RSSPHGSLGS VVNSLSGLKL DNILSGPKID VLKSGMKQAA TVASKMWVAV ASAYSYSDDE EETNRDYSFP AGLEDHILGE NISPNTSISG LVPSELTQSN TSLGSSSSSG DVGKLHYPTG EVPFPRGMKG QDFEKSDHGS SQNTSMSSIY QNCAMEVLMS SCSQCRACGA LVYDEEIMAG WTADDSNLNT ACPFCKSNFL PLLNIEFKDL RGSASFFLKP STSGDSLQSG SIPLANESLE HKPVSSLAEP DLINFMDFPK HNQIITEETG SAVEPSDEIK RASGDVQTMK ISSVPNSLSK RNVSLTRSHS VGGPLQNIDF TQRPFHGIST VSLPNSLQEV VDPLGKRPNP PPVSVPYLSP LVLRKELESL LENEGDQVIH TSSFINQHPI IFWNLVWYFR RLDLPSNLPG LILTSEHCNE GVQLPLSSLS QDSKLVYIQL LWDNINLHQE PREPLYVSWR NFNSEKKSSL LSEEQQETST LVETIRQSIQ HNNVLKPINL LSQQMKPGMK RQRSLYREIL FLSLVSLGRE NIDIEAFDNE YGIAYNSLSS EILERLQKID APPSASVEWC RKCFGAPLI
Explore DENN domain-containing protein 4C with MolForge
Find binders, run structure-based screening, and map this target across
diseases and approved drugs with our AI-powered platform.
Browse all targets