About Transmembrane protein 268
Transmembrane protein 268 (TMEM268) is a protein
from Homo sapiens identified by UniProt accession
Q5VZI3, 342 residues long.
MolForge cross-references it against 0 known binders and
22 disease associations.
Target properties
| Protein name | Transmembrane protein 268 |
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| UniProt accession | Q5VZI3 |
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| Gene | TMEM268 |
|---|
| Organism | Homo sapiens |
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| Length | 342 residues |
|---|
| Molecular weight | — |
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| EC numbers | — |
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| Target class | UNCLASSIFIED |
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| Subcellular location | — |
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| Keywords | — |
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Druggability
Target tractability assessment (Open Targets + pocket analysis). No approved drug
| Druggability tier | MEDIUM |
|---|
| Druggability score | — |
|---|
| Pocket score | — |
|---|
| Max clinical phase | — |
|---|
Disease associations (22)
Diseases linked to this target (Open Targets).
- serum metabolite measurement · score 0.31
- age at menarche · score 0.08
- hip bone mineral density · score 0.08
- Crohn's disease · score 0.06
- depressive episode measurement · score 0.04
- Sepsis · score 0.04
- asthma · score 0.03
- tenascin measurement · score 0.03
- body height · score 0.02
- neoplasm · score 0.01
3D Structure (1)
Experimental (PDB) and predicted (AlphaFold) structures for this protein.
| Structure | Source | Method | Mean pLDDT | Resolution (Å) |
|---|
| AF-Q5VZI3-F1 | alphafold | PREDICTED | 71.17 | — |
Amino-acid sequence (342 residues)
MACEPQVDPG ATGPLPPSSP GWSALPGGSP PGWGQELHNG QVLTVLRIDN TCAPISFDLG AAEEQLQTWG IQVPADQYRS LAESALLEPQ VRRYIIYNSR PMRLAFAVVF YVVVWANIYS TSQMFALGNH WAGMLLVTLA AVSLTLTLVL VFERHQKKAN TNTDLRLAAA NGALLRHRVL LGVTDTVEGC QSVIQLWFVY FDLENCVQFL SDHVQEMKTS QESLLRSRLS QLCVVMETGV SPATAEGPEN LEDAPLLPGN SCPNERPLMQ TELHQLVPEA EPEEMARQLL AVFGGYYIRL LVTSQLPQAM GTRHTNSPRI PCPCQLIEAY ILGTGCCPFL AR
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