Ras-related GTP-binding protein B (RRAGB)

About Ras-related GTP-binding protein B

Ras-related GTP-binding protein B (RRAGB) is a protein from Homo sapiens identified by UniProt accession Q5VZM2, 374 residues long. MolForge cross-references it against 0 known binders and 47 disease associations.

Target properties

Protein name	Ras-related GTP-binding protein B
UniProt accession	Q5VZM2
Gene	RRAGB
Organism	Homo sapiens
Length	374 residues
Molecular weight	—
EC numbers	—
Target class	UNCLASSIFIED
Subcellular location	—
Keywords	—

Druggability

Target tractability assessment (Open Targets + pocket analysis). No approved drug

Druggability tier	MEDIUM
Druggability score	—
Pocket score	—
Max clinical phase	—

Disease associations (47)

Diseases linked to this target (Open Targets).

breast adenocarcinoma · score 0.28
pancreatic adenocarcinoma · score 0.28
lung adenocarcinoma · score 0.27
endometrial cancer · score 0.23
head and neck squamous cell carcinoma · score 0.18
multiple myeloma · score 0.16
esophageal cancer · score 0.15
gastric adenocarcinoma · score 0.14
urinary bladder cancer · score 0.12
diabetes mellitus · score 0.10

3D Structure (1)

Experimental (PDB) and predicted (AlphaFold) structures for this protein.

Structure	Source	Method	Mean pLDDT	Resolution (Å)
AF-Q5VZM2-F1	alphafold	PREDICTED	81.71	—

Amino-acid sequence (374 residues)

MEESDSEKTT EKENLGPRMD PPLGEPEGSL GWVLPNTAMK KKVLLMGKSG SGKTSMRSII FANYIARDTR RLGATILDRI HSLQINSSLS TYSLVDSVGN TKTFDVEHSH VRFLGNLVLN LWDCGGQDTF MENYFTSQRD NIFRNVEVLI YVFDVESREL EKDMHYYQSC LEAILQNSPD AKIFCLVHKM DLVQEDQRDL IFKEREEDLR RLSRPLECSC FRTSIWDETL YKAWSSIVYQ LIPNVQQLEM NLRNFAEIIE ADEVLLFERA TFLVISHYQC KEQRDAHRFE KISNIIKQFK LSCSKLAASF QSMEVRNSNF AAFIDIFTSN TYVMVVMSDP SIPSAATLIN IRNARKHFEK LERVDGPKQC LLMR

External references

UniProt AlphaFold QuickGO RCSB PDB GeneCards