About NUT family member 2G
NUT family member 2G (NUTM2G) is a protein
from Homo sapiens identified by UniProt accession
Q5VZR2, 741 residues long.
MolForge cross-references it against 0 known binders and
61 disease associations.
Target properties
| Protein name | NUT family member 2G |
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| UniProt accession | Q5VZR2 |
|---|
| Gene | NUTM2G |
|---|
| Organism | Homo sapiens |
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| Length | 741 residues |
|---|
| Molecular weight | — |
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| EC numbers | — |
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| Target class | UNCLASSIFIED |
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| Subcellular location | — |
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| Keywords | — |
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Druggability
Target tractability assessment (Open Targets + pocket analysis). No approved drug
| Druggability tier | MEDIUM |
|---|
| Druggability score | — |
|---|
| Pocket score | — |
|---|
| Max clinical phase | — |
|---|
Disease associations (61)
Diseases linked to this target (Open Targets).
- neurodegenerative disease · score 0.53
- azoospermia · score 0.09
- Male infertility with spermatogenesis disorder due to single gene mutation · score 0.07
- Female infertility due to fertilization defect · score 0.07
- Rare genetic female infertility · score 0.07
- partial chromosome Y deletion · score 0.07
- male infertility with teratozoospermia due to single gene mutation · score 0.07
- spermatogenic failure 3 · score 0.06
- spermatogenic failure 55 · score 0.06
- spermatogenic failure 31 · score 0.06
3D Structure (1)
Experimental (PDB) and predicted (AlphaFold) structures for this protein.
| Structure | Source | Method | Mean pLDDT | Resolution (Å) |
|---|
| AF-Q5VZR2-F1 | alphafold | PREDICTED | 50.86 | — |
Amino-acid sequence (741 residues)
MASNGAYPVL GPGVTVNPGT SLSVFTALPF ATPSPGPTHR PPLVTAVVPP AGPLVLSAFP STPLVAGQDG RGPSGAGASN VFVQMRTEVG PVKPPQAQTL ILTQAPLVWQ APGTLCGGVM CPPPLLLAAA PGVPVTSAQV VGGTQACEGG WSHGLPLPPP PPAAQVAPIV SPGNAGPWPQ GAHGEGSLAP SQAKARPDDS CKPKSVYENF RLWQHYKPLA RRHLPQSPDT EALSCFLIPV LRSLARRKPT MTLEEGLWRA MREWQHTSNF DRMIFYEMAA KFLEFEAEEE MQIQKSQWMK GPQSLPPPAP PRLEPRGPPA PEVVKQPVYL PSKDGPKAPT ACLPPPRPQR PAETKAHLPP PRPPRPAETK VPEEIPPEVV QEYVDIMEEL LGSHPGDTGE PEGQREKGKV EQPQEEDGMT SDPGLLSYID KLCSQEDFVT KVEAVIHPRF LEELLSPDPQ MDFLALSQEL EQEEGLTLAQ LVEKRLLSLK EKGCGRAAPR HGTARLDSSP SEFAAGQEAA REVPDPQQRV SVETSPPQTA AQDPQGQGRV RTGMARSEDP AVLLGCQDSP RLKAVRPTSP PQDHRPTCPG LGTKDALGLP GESPVKESHG LAKGSSEETE LPGMVYVVGS HHRLRPWRLS QSPVPSSGLL SPGGRGPQGA LQSPSAQKRG LSPSPSPASK SKKRPLFGSP SPAEKTPHPG PGLRVSGEQS LAWGLGGPSQ SQKRKGDPLA SRRKKKRHCS Q
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