About F-box only protein 31
F-box only protein 31 (FBXO31) is a protein
from Homo sapiens identified by UniProt accession
Q5XUX0, 539 residues long.
MolForge cross-references it against 0 known binders and
56 disease associations.
Target properties
| Protein name | F-box only protein 31 |
|---|
| UniProt accession | Q5XUX0 |
|---|
| Gene | FBXO31 |
|---|
| Organism | Homo sapiens |
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| Length | 539 residues |
|---|
| Molecular weight | — |
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| EC numbers | — |
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| Target class | UNCLASSIFIED |
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| Subcellular location | — |
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| Keywords | — |
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Druggability
Target tractability assessment (Open Targets + pocket analysis). No approved drug
| Druggability tier | MEDIUM |
|---|
| Druggability score | — |
|---|
| Pocket score | — |
|---|
| Max clinical phase | — |
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Disease associations (56)
Diseases linked to this target (Open Targets).
- autosomal recessive non-syndromic intellectual disability · score 0.54
- intellectual disability, autosomal dominant · score 0.37
- neurodegenerative disease · score 0.37
- spastic cerebral palsy · score 0.26
- brain volume measurement · score 0.25
- self reported educational attainment · score 0.25
- neuroticism measurement · score 0.25
- mood instability measurement · score 0.23
- smoking status measurement · score 0.21
- smoking behaviour measurement · score 0.18
3D Structure (1)
Experimental (PDB) and predicted (AlphaFold) structures for this protein.
| Structure | Source | Method | Mean pLDDT | Resolution (Å) |
|---|
| AF-Q5XUX0-F1 | alphafold | PREDICTED | 83.06 | — |
Amino-acid sequence (539 residues)
MAVCARLCGV GPSRGCRRRQ QRRGPAETAA ADSEPDTDPE EERIEASAGV GGGLCAGPSP PPPRCSLLEL PPELLVEIFA SLPGTDLPSL AQVCTKFRRI LHTDTIWRRR CREEYGVCEN LRKLEITGVS CRDVYAKLLH RYRHILGLWQ PDIGPYGGLL NVVVDGLFII GWMYLPPHDP HVDDPMRFKP LFRIHLMERK AATVECMYGH KGPHHGHIQI VKKDEFSTKC NQTDHHRMSG GRQEEFRTWL REEWGRTLED IFHEHMQELI LMKFIYTSQY DNCLTYRRIY LPPSRPDDLI KPGLFKGTYG SHGLEIVMLS FHGRRARGTK ITGDPNIPAG QQTVEIDLRH RIQLPDLENQ RNFNELSRIV LEVRERVRQE QQEGGHEAGE GRGRQGPRES QPSPAQPRAE APSKGPDGTP GEDGGEPGDA VAAAEQPAQC GQGQPFVLPV GVSSRNEDYP RTCRMCFYGT GLIAGHGFTS PERTPGVFIL FDEDRFGFVW LELKSFSLYS RVQATFRNAD APSPQAFDEM LKNIQSLTS
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