Stabilizer of axonemal microtubules 2 (SAXO2)

About Stabilizer of axonemal microtubules 2

Stabilizer of axonemal microtubules 2 (SAXO2) is a protein from Homo sapiens identified by UniProt accession Q658L1, 398 residues long. MolForge cross-references it against 0 known binders and 27 disease associations.

Target properties

Protein name	Stabilizer of axonemal microtubules 2
UniProt accession	Q658L1
Gene	SAXO2
Organism	Homo sapiens
Length	398 residues
Molecular weight	—
EC numbers	—
Target class	UNCLASSIFIED
Subcellular location	—
Keywords	—

Druggability

Target tractability assessment (Open Targets + pocket analysis). No approved drug

Druggability tier	MEDIUM
Druggability score	—
Pocket score	—
Max clinical phase	—

Disease associations (27)

Diseases linked to this target (Open Targets).

self reported educational attainment · score 0.16
intelligence · score 0.14
cognitive function measurement · score 0.14
cerebellar volume measurement · score 0.14
testosterone measurement · score 0.12
erythrocyte count · score 0.10
skin pigmentation · score 0.10
creatinine measurement · score 0.10
episodic memory · score 0.07
schizophrenia · score 0.06

3D Structure (1)

Experimental (PDB) and predicted (AlphaFold) structures for this protein.

Structure	Source	Method	Mean pLDDT	Resolution (Å)
AF-Q658L1-F1	alphafold	PREDICTED	70.32	—

Amino-acid sequence (398 residues)

MGAKSMRSWC LCQICSCGSD YCPYEIVKQP RHVPEEYKPK QGKIDLGTTY KRDLNSYKVQ PVAIVRPLER QVKKGKLDTV PTYKDDYRAW DLHKSELYKP EQTYHPPTVK FGNSTTFQDD FVPQEIKPRQ SFKPSSVVKR STAPFNGITS HRLDYIPHQL ELKFERPKEV YKPTDQRFED LTTHRCDFQG LIGETAKLCR PVHTRVTQNA LFEGSTEFRE SFQPWEIPPP EVKKVPEYVP PTGSMLLNST SHLDYVPYQA NHVVPIRPVS QKRSNNFPFQ GKSIMKEDFP AWESCRQGLI KKQQQIPNPS GKFDGLSTFR SHYVPHELIP TESCKPLNIA FKSSVPFDDV TMYSVEYTPK RQEICPASYP SPPGYIFDNT NSQGHKFFRK IIPAVKAF

External references

UniProt AlphaFold QuickGO RCSB PDB GeneCards