Metalloreductase STEAP3 (STEAP3)

About Metalloreductase STEAP3

Metalloreductase STEAP3 (STEAP3) is a protein from Homo sapiens identified by UniProt accession Q658P3, 488 residues long. MolForge cross-references it against 0 known binders and 347 disease associations.

Target properties

Protein name	Metalloreductase STEAP3
UniProt accession	Q658P3
Gene	STEAP3
Organism	Homo sapiens
Length	488 residues
Molecular weight	—
EC numbers	—
Target class	UNCLASSIFIED
Subcellular location	—
Keywords	—

Druggability

Target tractability assessment (Open Targets + pocket analysis). No approved drug

Druggability tier	MEDIUM
Druggability score	—
Pocket score	—
Max clinical phase	—

Disease associations (347)

Diseases linked to this target (Open Targets).

severe congenital hypochromic anemia with ringed sideroblasts · score 0.51
glioblastoma multiforme · score 0.28
wellbeing measurement · score 0.26
breast adenocarcinoma · score 0.25
squamous cell lung carcinoma · score 0.23
endometrial cancer · score 0.23
gastric adenocarcinoma · score 0.23
head and neck squamous cell carcinoma · score 0.23
urinary bladder cancer · score 0.23
small cell lung carcinoma · score 0.17

3D Structure (1)

Experimental (PDB) and predicted (AlphaFold) structures for this protein.

Structure	Source	Method	Mean pLDDT	Resolution (Å)
AF-Q658P3-F1	alphafold	PREDICTED	89.20	—

Amino-acid sequence (488 residues)

MPEEMDKPLI SLHLVDSDSS LAKVPDEAPK VGILGSGDFA RSLATRLVGS GFKVVVGSRN PKRTARLFPS AAQVTFQEEA VSSPEVIFVA VFREHYSSLC SLSDQLAGKI LVDVSNPTEQ EHLQHRESNA EYLASLFPTC TVVKAFNVIS AWTLQAGPRD GNRQVPICGD QPEAKRAVSE MALAMGFMPV DMGSLASAWE VEAMPLRLLP AWKVPTLLAL GLFVCFYAYN FVRDVLQPYV QESQNKFFKL PVSVVNTTLP CVAYVLLSLV YLPGVLAAAL QLRRGTKYQR FPDWLDHWLQ HRKQIGLLSF FCAALHALYS FCLPLRRAHR YDLVNLAVKQ VLANKSHLWV EEEVWRMEIY LSLGVLALGT LSLLAVTSLP SIANSLNWRE FSFVQSSLGF VALVLSTLHT LTYGWTRAFE ESRYKFYLPP TFTLTLLVPC VVILAKALFL LPCISRRLAR IRRGWEREST IKFTLPTDHA LAEKTSHV

External references

UniProt AlphaFold QuickGO RCSB PDB GeneCards