About Protein FAM91A1
Protein FAM91A1 (FAM91A1) is a protein
from Homo sapiens identified by UniProt accession
Q658Y4, 838 residues long.
MolForge cross-references it against 0 known binders and
67 disease associations.
Target properties
| Protein name | Protein FAM91A1 |
|---|
| UniProt accession | Q658Y4 |
|---|
| Gene | FAM91A1 |
|---|
| Organism | Homo sapiens |
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| Length | 838 residues |
|---|
| Molecular weight | — |
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| EC numbers | — |
|---|
| Target class | UNCLASSIFIED |
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| Subcellular location | — |
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| Keywords | — |
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Druggability
Target tractability assessment (Open Targets + pocket analysis). No approved drug
| Druggability tier | MEDIUM |
|---|
| Druggability score | — |
|---|
| Pocket score | — |
|---|
| Max clinical phase | — |
|---|
Disease associations (67)
Diseases linked to this target (Open Targets).
- calcium measurement · score 0.18
- azoospermia · score 0.09
- Male infertility with spermatogenesis disorder due to single gene mutation · score 0.07
- Female infertility due to fertilization defect · score 0.07
- Rare genetic female infertility · score 0.07
- partial chromosome Y deletion · score 0.07
- male infertility with teratozoospermia due to single gene mutation · score 0.07
- spermatogenic failure 3 · score 0.06
- spermatogenic failure 55 · score 0.06
- spermatogenic failure 26 · score 0.06
3D Structure (1)
Experimental (PDB) and predicted (AlphaFold) structures for this protein.
| Structure | Source | Method | Mean pLDDT | Resolution (Å) |
|---|
| AF-Q658Y4-F1 | alphafold | PREDICTED | 77.00 | — |
Amino-acid sequence (838 residues)
MNIDVEFHIR HNYPWNKLPA NVRQSLGNSQ REYEKQVVLY SIRNQLRYRN NLVKHVKKDE RRYYEELLKY SRDHLMLYPY HLSDIMVKGL RITPFSYYTG IMEDIMNSEK SYDSLPNFTA ADCLRLLGIG RNQYIDLMNQ CRSSKKFFRR KTARDLLPIK PVEIAIEAWW VVQAGYITED DIKICTLPEK CAVDKIIDSG PQLSGSLDYN VVHSLYNKGF IYLDVPISDD SCIAVPPLEG FVMNRVQGDY FETLLYKIFV SIDEHTNVAE LANVLEIDLS LVKNAVSMYC RLGFAHKKGQ VINLDQLHSS WKNVPSVNRL KSTLDPQKML LSWDGGESRS PVQEASSATD TDTNSQEDPA DTASVSSLSL STGHTKRIAF LFDSTLTAFL MMGNLSPNLK SHAVTMFEVG KLSDESLDSF LIELEKVQST GEGEAQRYFD HALTLRNTIL FLRHNKDLVA QTAQPDQPNY GFPLDLLRCE SLLGLDPATC SRVLNKNYTL LVSMAPLTNE IRPVSSCTPQ HIGPAIPEVS SVWFKLYIYH VTGQGPPSLL LSKGTRLRKL PDIFQSYDRL LITSWGHDPG VVPTSNVLTM LNDALTHSAV LIQGHGLHGI GETVHVPFPF DETELQGEFT RVNMGVHKAL QILRNRVDLQ HLCGYVTMLN ASSQLADRKL SDASDERGEP DLASGSDVNG STESFEMVIE EATIDSATKQ TSGATTEADW VPLELCFGIP LFSSELNRKV CRKIAAHGLC RKESLQNLLH SSRKLSLQVL NFVHSFQEGA SILDIHTEPS FSSLLSQSSC ADMGVPLPAK NLIFKDGVLS EWSGRSPSSL LIANLHLQ
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