Metalloreductase STEAP4 (STEAP4)

About Metalloreductase STEAP4

Metalloreductase STEAP4 (STEAP4) is a protein from Homo sapiens identified by UniProt accession Q687X5, 459 residues long. MolForge cross-references it against 0 known binders and 145 disease associations.

Target properties

Protein name	Metalloreductase STEAP4
UniProt accession	Q687X5
Gene	STEAP4
Organism	Homo sapiens
Length	459 residues
Molecular weight	—
EC numbers	—
Target class	UNCLASSIFIED
Subcellular location	—
Keywords	—

Druggability

Target tractability assessment (Open Targets + pocket analysis). No approved drug

Druggability tier	MEDIUM
Druggability score	—
Pocket score	—
Max clinical phase	—

Disease associations (145)

Diseases linked to this target (Open Targets).

hepatocellular carcinoma · score 0.11
neoplasm · score 0.09
breast cancer · score 0.08
experimental autoimmune encephalomyelitis · score 0.07
colorectal carcinoma · score 0.07
gonorrhea · score 0.07
Rheumatoid arthritis · score 0.07
pulmonary arterial hypertension · score 0.07
adolescent idiopathic scoliosis · score 0.07
rheumatoid arthritis · score 0.07

3D Structure (1)

Experimental (PDB) and predicted (AlphaFold) structures for this protein.

Structure	Source	Method	Mean pLDDT	Resolution (Å)
AF-Q687X5-F1	alphafold	PREDICTED	90.93	—

Amino-acid sequence (459 residues)

MEKTCIDALP LTMNSSEKQE TVCIFGTGDF GRSLGLKMLQ CGYSVVFGSR NPQKTTLLPS GAEVLSYSEA AKKSGIIIIA IHREHYDFLT ELTEVLNGKI LVDISNNLKI NQYPESNAEY LAHLVPGAHV VKAFNTISAW ALQSGALDAS RQVFVCGNDS KAKQRVMDIV RNLGLTPMDQ GSLMAAKEIE KYPLQLFPMW RFPFYLSAVL CVFLFFYCVI RDVIYPYVYE KKDNTFRMAI SIPNRIFPIT ALTLLALVYL PGVIAAILQL YRGTKYRRFP DWLDHWMLCR KQLGLVALGF AFLHVLYTLV IPIRYYVRWR LGNLTVTQAI LKKENPFSTS SAWLSDSYVA LGILGFFLFV LLGITSLPSV SNAVNWREFR FVQSKLGYLT LILCTAHTLV YGGKRFLSPS NLRWYLPAAY VLGLIIPCTV LVIKFVLIMP CVDNTLTRIR QGWERNSKH

External references

UniProt AlphaFold QuickGO RCSB PDB GeneCards