About Protein SPT2 homolog
Protein SPT2 homolog (SPTY2D1) is a protein
from Homo sapiens identified by UniProt accession
Q68D10, 685 residues long.
MolForge cross-references it against 0 known binders and
85 disease associations.
Target properties
| Protein name | Protein SPT2 homolog |
|---|
| UniProt accession | Q68D10 |
|---|
| Gene | SPTY2D1 |
|---|
| Organism | Homo sapiens |
|---|
| Length | 685 residues |
|---|
| Molecular weight | — |
|---|
| EC numbers | — |
|---|
| Target class | UNCLASSIFIED |
|---|
| Subcellular location | — |
|---|
| Keywords | — |
|---|
Druggability
Target tractability assessment (Open Targets + pocket analysis). No approved drug
| Druggability tier | MEDIUM |
|---|
| Druggability score | — |
|---|
| Pocket score | — |
|---|
| Max clinical phase | — |
|---|
Disease associations (85)
Diseases linked to this target (Open Targets).
- neurodegenerative disease · score 0.44
- low density lipoprotein cholesterol measurement · score 0.29
- body height · score 0.28
- total cholesterol measurement · score 0.28
- serum albumin measurement · score 0.25
- appendicular lean mass · score 0.25
- apolipoprotein B measurement · score 0.24
- alcohol drinking · score 0.23
- mean corpuscular volume · score 0.21
- fat body mass · score 0.19
3D Structure (1)
Experimental (PDB) and predicted (AlphaFold) structures for this protein.
| Structure | Source | Method | Mean pLDDT | Resolution (Å) |
|---|
| AF-Q68D10-F1 | alphafold | PREDICTED | 55.85 | — |
Amino-acid sequence (685 residues)
MDFREILMIA SKGQGVNNVP KRYSLAVGPP KKDPKVKGVQ SAAVQAFLKR KEEELRRKAL EEKRRKEELV KKRIELKHDK KARAMAKRTK DNFHGYNGIP IEEKSKKRQA TESHTSQGTD REYEMEEENE FLEYNHAESE QEYEEEQEPP KVESKPKVPL KSAPPPMNFT DLLRLAEKKQ FEPVEIKVVK KSEERPMTAE ELREREFLER KHRRKKLETD GKLPPTVSKK APSQKESVGT KLSKGSGDRH PSSKGMPLPH AEKKSRPSMA NEKHLALSSS KSMPGERIKA GSGNSSQPSL REGHDKPVFN GAGKPHSSTS SPSVPKTSAS RTQKSAVEHK AKKSLSHPSH SRPGPMVTPH NKAKSPGVRQ PGSSSSSAPG QPSTGVARPT VSSGPVPRRQ NGSSSSGPER SISGSKKPTN DSNPSRRTVS GTCGPGQPAS SSGGPGRPIS GSVSSARPLG SSRGPGRPVS SPHELRRPVS GLGPPGRSVS GPGRSISGSI PAGRTVSNSV PGRPVSSLGP GQTVSSSGPT IKPKCTVVSE TISSKNIISR SSNGQMNGMK PPLSGYRAAQ GPQRLPFPTG YKRQREYEEE DDDDDEYDSE MEDFIEDEGE PQEEISKHIR EIFGYDRKKY KDESDYALRY MESSWKEQQK EEAKSLRLGM QEDLEEMRRE EEEMQRRRAK KLKRR
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