About Transmembrane protein 215
Transmembrane protein 215 (TMEM215) is a protein
from Homo sapiens identified by UniProt accession
Q68D42, 235 residues long.
MolForge cross-references it against 0 known binders and
10 disease associations.
Target properties
| Protein name | Transmembrane protein 215 |
|---|
| UniProt accession | Q68D42 |
|---|
| Gene | TMEM215 |
|---|
| Organism | Homo sapiens |
|---|
| Length | 235 residues |
|---|
| Molecular weight | — |
|---|
| EC numbers | — |
|---|
| Target class | UNCLASSIFIED |
|---|
| Subcellular location | — |
|---|
| Keywords | — |
|---|
Druggability
Target tractability assessment (Open Targets + pocket analysis). No approved drug
| Druggability tier | MEDIUM |
|---|
| Druggability score | — |
|---|
| Pocket score | — |
|---|
| Max clinical phase | — |
|---|
Disease associations (10)
Diseases linked to this target (Open Targets).
- peripheral neuropathy · score 0.11
- PHF-tau measurement · score 0.04
- Down syndrome · score 0.03
- papillary thyroid carcinoma · score 0.02
- neoplasm · score 0.01
- breast carcinoma · score 0.01
- ulcerative colitis · score 0.01
- cancer · score 0.00
- Crohn's disease · score 0.00
- Infertility · score 0.00
3D Structure (1)
Experimental (PDB) and predicted (AlphaFold) structures for this protein.
| Structure | Source | Method | Mean pLDDT | Resolution (Å) |
|---|
| AF-Q68D42-F1 | alphafold | PREDICTED | 52.98 | — |
Amino-acid sequence (235 residues)
MRPDDINPRT GLVVALVSVF LVFGFMFTVS GMKGETLGNI PLLAIGPAIC LPGIAAIALA RKTEGCTKWP ENELLWVRKL PCFRKPKDKE VVELLRTPSD LESGKGSSDE LAKKAGLRGK PPPQSQGEVS VASSINSPTP TEEGECQSLV QNGHQEETSR YLDGYCPSGS SLTYSALDVK CSARDRSECP EPEDSIFFVP QDSIIVCSYK QNSPYDRYCC YINQIQGRWD HETIV
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