About LEM domain-containing protein 1
LEM domain-containing protein 1 (LEMD1) is a protein
from Homo sapiens identified by UniProt accession
Q68G75, 181 residues long.
MolForge cross-references it against 0 known binders and
44 disease associations.
Target properties
| Protein name | LEM domain-containing protein 1 |
|---|
| UniProt accession | Q68G75 |
|---|
| Gene | LEMD1 |
|---|
| Organism | Homo sapiens |
|---|
| Length | 181 residues |
|---|
| Molecular weight | — |
|---|
| EC numbers | — |
|---|
| Target class | UNCLASSIFIED |
|---|
| Subcellular location | — |
|---|
| Keywords | — |
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Druggability
Target tractability assessment (Open Targets + pocket analysis). No approved drug
| Druggability tier | MEDIUM |
|---|
| Druggability score | — |
|---|
| Pocket score | — |
|---|
| Max clinical phase | — |
|---|
Disease associations (44)
Diseases linked to this target (Open Targets).
- blood urea nitrogen measurement · score 0.29
- sleep measurement · score 0.20
- PHF-tau measurement · score 0.14
- oral squamous cell carcinoma · score 0.10
- triple-negative breast cancer · score 0.08
- pachyonychia congenita · score 0.07
- cancer · score 0.07
- Treacher-Collins syndrome · score 0.05
- neoplasm · score 0.05
- non-small cell lung carcinoma · score 0.05
3D Structure (1)
Experimental (PDB) and predicted (AlphaFold) structures for this protein.
| Structure | Source | Method | Mean pLDDT | Resolution (Å) |
|---|
| AF-Q68G75-F1 | alphafold | PREDICTED | 64.51 | — |
Amino-acid sequence (181 residues)
MVDVKCLSDC KLQNQLEKLG FSPGPILPST RKLYEKKLVQ LLVSPPCAPP VMNGPRELDG AQDSDDSEEL NIILQGNIIL STEKSKKLKK WPEASTTKRK AVDTYCLDYK PSKGRRWAAR APSTRITYGT ITKERDYCAE DQTIESWREE GFPVGLKLAV LGIFIIVVFV YLTVENKSLF G
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