Nuclear apoptosis-inducing factor 1 (NAIF1)

About Nuclear apoptosis-inducing factor 1

Nuclear apoptosis-inducing factor 1 (NAIF1) is a protein from Homo sapiens identified by UniProt accession Q69YI7, 327 residues long. MolForge cross-references it against 0 known binders and 19 disease associations.

Target properties

Protein name	Nuclear apoptosis-inducing factor 1
UniProt accession	Q69YI7
Gene	NAIF1
Organism	Homo sapiens
Length	327 residues
Molecular weight	—
EC numbers	—
Target class	UNCLASSIFIED
Subcellular location	—
Keywords	—

Druggability

Target tractability assessment (Open Targets + pocket analysis). No approved drug

Druggability tier	MEDIUM
Druggability score	—
Pocket score	—
Max clinical phase	—

Disease associations (19)

Diseases linked to this target (Open Targets).

neurodegenerative disease · score 0.23
monocyte count · score 0.08
osteosarcoma · score 0.07
myeloid white cell count · score 0.05
neutrophil count · score 0.04
neoplasm · score 0.02
systolic blood pressure · score 0.02
hemoglobin measurement · score 0.02
erythrocyte count · score 0.02
cancer · score 0.02

3D Structure (1)

Experimental (PDB) and predicted (AlphaFold) structures for this protein.

Structure	Source	Method	Mean pLDDT	Resolution (Å)
AF-Q69YI7-F1	alphafold	PREDICTED	69.90	—

Amino-acid sequence (327 residues)

MAVPAKKRKM NFSEREVEII VEELELKKHL LVNHFNAGVP LAAKSAAWHG ILRRVNAVAT CRRELPEVKK KWSDLKTEVR RKVAQVRAAV EGGEAPGPTE EDGAGGPGTG GGSGGGGPAV APVLLTPMQQ RICNLLGEAT IISLPSTTEI HPVALGPSAT AAAATVTLTQ IPTETTYHTL EEGVVEYCTA EAPPPLPPET PVDMMAQHAD TSVKPQALKS RIALNSAKLI QEQRVTNLHV KEIAQHLEQQ NDLLQMIRRS QEVQACAQER QAQAMEGTQA ALSVLIQVLR PMIKDFRRYL QSNTANPAPA SDPGQVAQNG QPDSIIQ

External references

UniProt AlphaFold QuickGO RCSB PDB GeneCards