Thioredoxin domain-containing protein 8 (TXNDC8)

About Thioredoxin domain-containing protein 8

Thioredoxin domain-containing protein 8 (TXNDC8) is a protein from Homo sapiens identified by UniProt accession Q6A555, 127 residues long. MolForge cross-references it against 0 known binders and 40 disease associations.

Target properties

Protein name	Thioredoxin domain-containing protein 8
UniProt accession	Q6A555
Gene	TXNDC8
Organism	Homo sapiens
Length	127 residues
Molecular weight	—
EC numbers	—
Target class	UNCLASSIFIED
Subcellular location	—
Keywords	—

Druggability

Target tractability assessment (Open Targets + pocket analysis). No approved drug

Druggability tier	MEDIUM
Druggability score	—
Pocket score	—
Max clinical phase	—

Disease associations (40)

Diseases linked to this target (Open Targets).

blood protein measurement · score 0.18
platelet count · score 0.16
cardiovascular disease · score 0.15
systolic blood pressure · score 0.14
Calcium channel blocker use measurement · score 0.14
hypertension · score 0.14
mean platelet volume · score 0.14
diastolic blood pressure · score 0.13
Takayasu arteritis · score 0.13
sex hormone-binding globulin measurement · score 0.12

3D Structure (1)

Experimental (PDB) and predicted (AlphaFold) structures for this protein.

Structure	Source	Method	Mean pLDDT	Resolution (Å)
AF-Q6A555-F1	alphafold	PREDICTED	85.07	—

Amino-acid sequence (127 residues)

MVQIIKDTNE FKTFLTAAGH KLAVVQFSSK RCGPCKRMFP VFHAMSVKYQ NVFFANVDVN NSPELAETCH IKTIPTFQMF KKSQKVTLFS RIKRIICCYR SGFMSNLIFE FCGADAKKLE AKTQELM

External references

UniProt AlphaFold QuickGO RCSB PDB GeneCards