E3 ubiquitin-protein ligase TRIM68 (TRIM68)

About E3 ubiquitin-protein ligase TRIM68

E3 ubiquitin-protein ligase TRIM68 (TRIM68) is a protein from Homo sapiens identified by UniProt accession Q6AZZ1, 485 residues long. MolForge cross-references it against 0 known binders and 32 disease associations.

Target properties

Protein name	E3 ubiquitin-protein ligase TRIM68
UniProt accession	Q6AZZ1
Gene	TRIM68
Organism	Homo sapiens
Length	485 residues
Molecular weight	—
EC numbers	—
Target class	UNCLASSIFIED
Subcellular location	—
Keywords	—

Druggability

Target tractability assessment (Open Targets + pocket analysis). No approved drug

Druggability tier	MEDIUM
Druggability score	—
Pocket score	—
Max clinical phase	—

Disease associations (32)

Diseases linked to this target (Open Targets).

neurodegenerative disease · score 0.43
reticulocyte count · score 0.20
reticulocyte measurement · score 0.20
PHF-tau measurement · score 0.16
body height · score 0.11
monocyte count · score 0.09
age-related macular degeneration · score 0.07
X-linked retinal dysplasia · score 0.06
severe early-childhood-onset retinal dystrophy · score 0.05
age related macular degeneration 7 · score 0.05

3D Structure (1)

Experimental (PDB) and predicted (AlphaFold) structures for this protein.

Structure	Source	Method	Mean pLDDT	Resolution (Å)
AF-Q6AZZ1-F1	alphafold	PREDICTED	88.03	—

Amino-acid sequence (485 residues)

MDPTALVEAI VEEVACPICM TFLREPMSID CGHSFCHSCL SGLWEIPGES QNWGYTCPLC RAPVQPRNLR PNWQLANVVE KVRLLRLHPG MGLKGDLCER HGEKLKMFCK EDVLIMCEAC SQSPEHEAHS VVPMEDVAWE YKWELHEALE HLKKEQEEAW KLEVGERKRT ATWKIQVETR KQSIVWEFEK YQRLLEKKQP PHRQLGAEVA AALASLQREA AETMQKLELN HSELIQQSQV LWRMIAELKE RSQRPVRWML QDIQEVLNRS KSWSLQQPEP ISLELKTDCR VLGLREILKT YAADVRLDPD TAYSRLIVSE DRKRVHYGDT NQKLPDNPER FYRYNIVLGS QCISSGRHYW EVEVGDRSEW GLGVCKQNVD RKEVVYLSPH YGFWVIRLRK GNEYRAGTDE YPILSLPVPP RRVGIFVDYE AHDISFYNVT DCGSHIFTFP RYPFPGRLLP YFSPCYSIGT NNTAPLAICS LDGED

External references

UniProt AlphaFold QuickGO RCSB PDB GeneCards