Atlastin-3 (ATL3)

About Atlastin-3

Atlastin-3 (ATL3) is a protein from Homo sapiens identified by UniProt accession Q6DD88, 541 residues long. MolForge cross-references it against 0 known binders and 34 disease associations.

Target properties

Protein name	Atlastin-3
UniProt accession	Q6DD88
Gene	ATL3
Organism	Homo sapiens
Length	541 residues
Molecular weight	—
EC numbers	—
Target class	UNCLASSIFIED
Subcellular location	—
Keywords	—

Druggability

Target tractability assessment (Open Targets + pocket analysis). No approved drug

Druggability tier	MEDIUM
Druggability score	—
Pocket score	—
Max clinical phase	—

Disease associations (34)

Diseases linked to this target (Open Targets).

neuropathy, hereditary sensory, type 1F · score 0.66
hereditary sensory and autonomic neuropathy type 1 · score 0.58
genetic disorder · score 0.19
Charcot-Marie-Tooth disease · score 0.11
prostate cancer · score 0.11
Charcot-Marie-Tooth disease axonal type 2N · score 0.11
Familial prostate cancer · score 0.11
prostate carcinoma · score 0.11
COVID-19 · score 0.02
Flavivirus Infections · score 0.01

3D Structure (1)

Experimental (PDB) and predicted (AlphaFold) structures for this protein.

Structure	Source	Method	Mean pLDDT	Resolution (Å)
AF-Q6DD88-F1	alphafold	PREDICTED	86.80	—

Amino-acid sequence (541 residues)

MLSPQRVAAA ASRGADDAME SSKPGPVQVV LVQKDQHSFE LDEKALASIL LQDHIRDLDV VVVSVAGAFR KGKSFILDFM LRYLYSQKES GHSNWLGDPE EPLTGFSWRG GSDPETTGIQ IWSEVFTVEK PGGKKVAVVL MDTQGAFDSQ STVKDCATIF ALSTMTSSVQ IYNLSQNIQE DDLQQLQLFT EYGRLAMDEI FQKPFQTLMF LVRDWSFPYE YSYGLQGGMA FLDKRLQVKE HQHEEIQNVR NHIHSCFSDV TCFLLPHPGL QVATSPDFDG KLKDIAGEFK EQLQALIPYV LNPSKLMEKE INGSKVTCRG LLEYFKAYIK IYQGEDLPHP KSMLQATAEA NNLAAAASAK DIYYNNMEEV CGGEKPYLSP DILEEKHCEF KQLALDHFKK TKKMGGKDFS FRYQQELEEE IKELYENFCK HNGSKNVFST FRTPAVLFTG IVALYIASGL TGFIGLEVVA QLFNCMVGLL LIALLTWGYI RYSGQYRELG GAIDFGAAYV LEQASSHIGN STQATVRDAV VGRPSMDKKA Q

External references

UniProt AlphaFold QuickGO RCSB PDB GeneCards