Galectin-9C (LGALS9C)

About Galectin-9C

Galectin-9C (LGALS9C) is a protein from Homo sapiens identified by UniProt accession Q6DKI2, 356 residues long. MolForge cross-references it against 0 known binders and 139 disease associations.

Target properties

Protein name	Galectin-9C
UniProt accession	Q6DKI2
Gene	LGALS9C
Organism	Homo sapiens
Length	356 residues
Molecular weight	—
EC numbers	—
Target class	UNCLASSIFIED
Subcellular location	—
Keywords	—

Druggability

Target tractability assessment (Open Targets + pocket analysis). No approved drug

Druggability tier	MEDIUM
Druggability score	—
Pocket score	—
Max clinical phase	—

Disease associations (139)

Diseases linked to this target (Open Targets).

mean corpuscular volume · score 0.38
mean corpuscular hemoglobin concentration · score 0.35
Familial hemophagocytic lymphohistiocytosis · score 0.05
Felty's syndrome · score 0.05
immunodeficiency 72 with autoinflammation · score 0.05
hyper-IgM syndrome type 3 · score 0.05
osteoarthritis · score 0.05
immunodeficiency 99 with hypogammaglobulinemia and autoimmune cytopenias · score 0.05
glycoprotein storage disease · score 0.05
common variable immunodeficiency · score 0.05

3D Structure (1)

Experimental (PDB) and predicted (AlphaFold) structures for this protein.

Structure	Source	Method	Mean pLDDT	Resolution (Å)
AF-Q6DKI2-F1	alphafold	PREDICTED	84.22	—

Amino-acid sequence (356 residues)

MAFSGCQAPY LSPAVPFSGT IQGGLQDGFQ ITVNGAVLSC SGTRFAVDFQ TGFSGNDIAF HFNPRFEDGG YVVCNTRQKG TWGPEERKMH MPFQKGMPFD LCFLVQSSDF KVMVNGSLFV QYFHRVPFHR VDTISVNGSV QLSYISFQNP RAVPVQPAFS TVPFSQPVCF PPRPRGRRQK PPSVRPANPA PITQTVIHTV QSASGQMFSQ TPAIPPMMYP HPAYPMPFIT TIPGGLYPSK SIILSGTVLP SAQRFHINLC SGSHIAFHMN PRFDENAVVR NTQINNSWGS EERSLPRKMP FVRGQSFSVW ILCEAHCLKV AVDGQHVFEY YHRLRNLPTI NKLEVGGDIQ LTHVQT

External references

UniProt AlphaFold QuickGO RCSB PDB GeneCards