About Tetratricopeptide repeat protein 19, mitochondrial
Tetratricopeptide repeat protein 19, mitochondrial (TTC19) is a protein
from Homo sapiens identified by UniProt accession
Q6DKK2, 380 residues long.
MolForge cross-references it against 0 known binders and
63 disease associations.
Target properties
| Protein name | Tetratricopeptide repeat protein 19, mitochondrial |
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| UniProt accession | Q6DKK2 |
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| Gene | TTC19 |
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| Organism | Homo sapiens |
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| Length | 380 residues |
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| Molecular weight | — |
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| EC numbers | — |
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| Target class | UNCLASSIFIED |
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| Subcellular location | — |
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| Keywords | — |
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Druggability
Target tractability assessment (Open Targets + pocket analysis). No approved drug
| Druggability tier | MEDIUM |
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| Druggability score | — |
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| Pocket score | — |
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| Max clinical phase | — |
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Disease associations (63)
Diseases linked to this target (Open Targets).
- Isolated CoQ-cytochrome C reductase deficiency · score 0.77
- mitochondrial complex III deficiency · score 0.55
- genetic disorder · score 0.45
- Leigh syndrome · score 0.37
- mitochondrial disease · score 0.34
- neurodegenerative disease · score 0.27
- vital capacity · score 0.20
- IGF-1 measurement · score 0.19
- mitochondrial complex III deficiency nuclear type 1 · score 0.19
- bilirubin measurement · score 0.18
3D Structure (1)
Experimental (PDB) and predicted (AlphaFold) structures for this protein.
| Structure | Source | Method | Mean pLDDT | Resolution (Å) |
|---|
| AF-Q6DKK2-F1 | alphafold | PREDICTED | 79.19 | — |
Amino-acid sequence (380 residues)
MFRLLSWSLG RGFLRAAGRR CRGCSARLLP GLAGGPGPEV QVPPSRVAPH GRGPGLLPLL AALAWFSRPA AAEEEEQQGA DGAAAEDGAD EAEAEIIQLL KRAKLSIMKD EPEEAELILH DALRLAYQTD NKKAITYTYD LMANLAFIRG QLENAEQLFK ATMSYLLGGG MKQEDNAIIE ISLKLASIYA AQNRQEFAVA GYEFCISTLE EKIEREKELA EDIMSVEEKA NTHLLLGMCL DACARYLLFS KQPSQAQRMY EKALQISEEI QGERHPQTIV LMSDLATTLD AQGRFDEAYI YMQRASDLAR QINHPELHMV LSNLAAVLMH RERYTQAKEI YQEALKQAKL KKDEISVQHI REELAELSKK SRPLTNSVKL
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