Histone H2A type 2-A (H2AC18)

About Histone H2A type 2-A

Histone H2A type 2-A (H2AC18) is a protein from Homo sapiens identified by UniProt accession Q6FI13, 130 residues long. MolForge cross-references it against 0 known binders and 18 disease associations.

Target properties

Protein name	Histone H2A type 2-A
UniProt accession	Q6FI13
Gene	H2AC18
Organism	Homo sapiens
Length	130 residues
Molecular weight	—
EC numbers	—
Target class	UNCLASSIFIED
Subcellular location	—
Keywords	—

Druggability

Target tractability assessment (Open Targets + pocket analysis). No approved drug

Druggability tier	MEDIUM
Druggability score	—
Pocket score	—
Max clinical phase	—

Disease associations (18)

Diseases linked to this target (Open Targets).

viral disease · score 0.50
infectious disease · score 0.50
breast carcinoma · score 0.37
cancer · score 0.37
melanoma · score 0.37
triglyceride measurement · score 0.04
age at menopause · score 0.03
vital capacity · score 0.03
high density lipoprotein cholesterol measurement · score 0.02
hepatocellular carcinoma · score 0.00

3D Structure (1)

Experimental (PDB) and predicted (AlphaFold) structures for this protein.

Structure	Source	Method	Mean pLDDT	Resolution (Å)
AF-Q6FI13-F1	alphafold	PREDICTED	90.98	—

Amino-acid sequence (130 residues)

MSGRGKQGGK ARAKAKSRSS RAGLQFPVGR VHRLLRKGNY AERVGAGAPV YMAAVLEYLT AEILELAGNA ARDNKKTRII PRHLQLAIRN DEELNKLLGK VTIAQGGVLP NIQAVLLPKK TESHHKAKGK

External references

UniProt AlphaFold QuickGO RCSB PDB GeneCards