Peroxisomal reductase activating PPAR-gamma (DHRS7B)

About Peroxisomal reductase activating PPAR-gamma

Peroxisomal reductase activating PPAR-gamma (DHRS7B) is a protein from Homo sapiens identified by UniProt accession Q6IAN0, 325 residues long. MolForge cross-references it against 0 known binders and 34 disease associations.

Target properties

Protein name	Peroxisomal reductase activating PPAR-gamma
UniProt accession	Q6IAN0
Gene	DHRS7B
Organism	Homo sapiens
Length	325 residues
Molecular weight	—
EC numbers	—
Target class	UNCLASSIFIED
Subcellular location	—
Keywords	—

Druggability

Target tractability assessment (Open Targets + pocket analysis). No approved drug

Druggability tier	MEDIUM
Druggability score	—
Pocket score	—
Max clinical phase	—

Disease associations (34)

Diseases linked to this target (Open Targets).

neurodegenerative disease · score 0.31
hematocrit · score 0.27
hemoglobin measurement · score 0.25
urate measurement · score 0.17
myeloid white cell count · score 0.16
uric acid measurement · score 0.16
neutrophil count · score 0.12
isolated asymptomatic elevation of creatine phosphokinase · score 0.05
hypertriglyceridemia 2 · score 0.05
cholesterol-ester transfer protein deficiency · score 0.05

3D Structure (1)

Experimental (PDB) and predicted (AlphaFold) structures for this protein.

Structure	Source	Method	Mean pLDDT	Resolution (Å)
AF-Q6IAN0-F1	alphafold	PREDICTED	92.79	—

Amino-acid sequence (325 residues)

MVSPATRKSL PKVKAMDFIT STAILPLLFG CLGVFGLFRL LQWVRGKAYL RNAVVVITGA TSGLGKECAK VFYAAGAKLV LCGRNGGALE ELIRELTASH ATKVQTHKPY LVTFDLTDSG AIVAAAAEIL QCFGYVDILV NNAGISYRGT IMDTTVDVDK RVMETNYFGP VALTKALLPS MIKRRQGHIV AISSIQGKMS IPFRSAYAAS KHATQAFFDC LRAEMEQYEI EVTVISPGYI HTNLSVNAIT ADGSRYGVMD TTTAQGRSPV EVAQDVLAAV GKKKKDVILA DLLPSLAVYL RTLAPGLFFS LMASRARKER KSKNS

External references

UniProt AlphaFold QuickGO RCSB PDB GeneCards