About IQ domain-containing protein E
IQ domain-containing protein E (IQCE) is a protein
from Homo sapiens identified by UniProt accession
Q6IPM2, 695 residues long.
MolForge cross-references it against 0 known binders and
58 disease associations.
Target properties
| Protein name | IQ domain-containing protein E |
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| UniProt accession | Q6IPM2 |
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| Gene | IQCE |
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| Organism | Homo sapiens |
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| Length | 695 residues |
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| Molecular weight | — |
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| EC numbers | — |
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| Target class | UNCLASSIFIED |
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| Subcellular location | — |
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| Keywords | — |
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Druggability
Target tractability assessment (Open Targets + pocket analysis). No approved drug
| Druggability tier | MEDIUM |
|---|
| Druggability score | — |
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| Pocket score | — |
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| Max clinical phase | — |
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Disease associations (58)
Diseases linked to this target (Open Targets).
- postaxial polydactyly type A · score 0.69
- polydactyly, postaxial, type A1 · score 0.46
- brachydactyly · score 0.34
- retinal degeneration · score 0.34
- syndactyly · score 0.34
- adolescent idiopathic scoliosis · score 0.28
- panic disorder · score 0.28
- anxiety disorder · score 0.28
- genetic disorder · score 0.27
- mean corpuscular volume · score 0.14
3D Structure (1)
Experimental (PDB) and predicted (AlphaFold) structures for this protein.
| Structure | Source | Method | Mean pLDDT | Resolution (Å) |
|---|
| AF-Q6IPM2-F1 | alphafold | PREDICTED | 68.06 | — |
Amino-acid sequence (695 residues)
MFLGTGEPAL DTGDDSLSAV TFDSDVETKA KRKAFHKPPP TSPKSPYLSK PRKVASWRSL RTAGSMPLGG RASLTPQKLW LGTAKPGSLT QALNSPLTWE HAWTGVPGGT PDCLTDTFRV KRPHLRRSAS NGHVPGTPVY REKEDMYDEI IELKKSLHVQ KSDVDLMRTK LRRLEEENSR KDRQIEQLLD PSRGTDFVRT LAEKRPDASW VINGLKQRIL KLEQQCKEKD GTISKLQTDM KTTNLEEMRI AMETYYEEVH RLQTLLASSE TTGKKPLGEK KTGAKRQKKM GSALLSLSRS VQELTEENQS LKEDLDRVLS TSPTISKTQG YVEWSKPRLL RRIVELEKKL SVMESSKSHA AEPVRSHPPA CLASSSALHR QPRGDRNKDH ERLRGAVRDL KEERTALQEQ LLQRDLEVKQ LLQAKADLEK ELECAREGEE ERREREEVLR EEIQTLTSKL QELQEMKKEE KEDCPEVPHK AQELPAPTPS SRHCEQDWPP DSSEEGLPRP RSPCSDGRRD AAARVLQAQW KVYKHKKKKA VLDEAAVVLQ AAFRGHLTRT KLLASKAHGS EPPSVPGLPD QSSPVPRVPS PIAQATGSPV QEEAIVIIQS ALRAHLARAR HSATGKRTTT AASTRRRSAS ATHGDASSPP FLAALPDPSP SGPQALAPLP GDDVNSDDSD DIVIAPSLPT KNFPV
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