About Grainyhead-like protein 2 homolog
Grainyhead-like protein 2 homolog (GRHL2) is a protein
from Homo sapiens identified by UniProt accession
Q6ISB3, 625 residues long.
MolForge cross-references it against 0 known binders and
193 disease associations.
Target properties
| Protein name | Grainyhead-like protein 2 homolog |
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| UniProt accession | Q6ISB3 |
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| Gene | GRHL2 |
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| Organism | Homo sapiens |
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| Length | 625 residues |
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| Molecular weight | — |
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| EC numbers | — |
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| Target class | UNCLASSIFIED |
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| Subcellular location | — |
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| Keywords | — |
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Druggability
Target tractability assessment (Open Targets + pocket analysis). No approved drug
| Druggability tier | MEDIUM |
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| Druggability score | — |
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| Pocket score | — |
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| Max clinical phase | — |
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Disease associations (193)
Diseases linked to this target (Open Targets).
- nail and teeth abnormalities-marginal palmoplantar keratoderma-oral hyperpigmentation syndrome · score 0.71
- posterior polymorphous corneal dystrophy · score 0.60
- autosomal dominant nonsyndromic hearing loss 28 · score 0.57
- autosomal dominant nonsyndromic hearing loss · score 0.53
- lymphocyte count · score 0.43
- breast carcinoma · score 0.41
- creatinine measurement · score 0.41
- neurodegenerative disease · score 0.37
- nonsyndromic genetic hearing loss · score 0.37
- rheumatoid arthritis · score 0.35
3D Structure (1)
Experimental (PDB) and predicted (AlphaFold) structures for this protein.
| Structure | Source | Method | Mean pLDDT | Resolution (Å) |
|---|
| AF-Q6ISB3-F1 | alphafold | PREDICTED | 66.87 | — |
Amino-acid sequence (625 residues)
MSQESDNNKR LVALVPMPSD PPFNTRRAYT SEDEAWKSYL ENPLTAATKA MMSINGDEDS AAALGLLYDY YKVPRDKRLL SVSKASDSQE DQEKRNCLGT SEAQSNLSGG ENRVQVLKTV PVNLSLNQDH LENSKREQYS ISFPESSAII PVSGITVVKA EDFTPVFMAP PVHYPRGDGE EQRVVIFEQT QYDVPSLATH SAYLKDDQRS TPDSTYSESF KDAATEKFRS ASVGAEEYMY DQTSSGTFQY TLEATKSLRQ KQGEGPMTYL NKGQFYAITL SETGDNKCFR HPISKVRSVV MVVFSEDKNR DEQLKYWKYW HSRQHTAKQR VLDIADYKES FNTIGNIEEI AYNAVSFTWD VNEEAKIFIT VNCLSTDFSS QKGVKGLPLM IQIDTYSYNN RSNKPIHRAY CQIKVFCDKG AERKIRDEER KQNRKKGKGQ ASQTQCNSSS DGKLAAIPLQ KKSDITYFKT MPDLHSQPVL FIPDVHFANL QRTGQVYYNT DDEREGGSVL VKRMFRPMEE EFGPVPSKQM KEEGTKRVLL YVRKETDDVF DALMLKSPTV KGLMEAISEK YGLPVEKIAK LYKKSKKGIL VNMDDNIIEH YSNEDTFILN MESMVEGFKV TLMEI
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