About Leukocyte-associated immunoglobulin-like receptor 2
Leukocyte-associated immunoglobulin-like receptor 2 (LAIR2) is a protein
from Homo sapiens identified by UniProt accession
Q6ISS4, 152 residues long.
MolForge cross-references it against 0 known binders and
300 disease associations.
Target properties
| Protein name | Leukocyte-associated immunoglobulin-like receptor 2 |
|---|
| UniProt accession | Q6ISS4 |
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| Gene | LAIR2 |
|---|
| Organism | Homo sapiens |
|---|
| Length | 152 residues |
|---|
| Molecular weight | — |
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| EC numbers | — |
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| Target class | UNCLASSIFIED |
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| Subcellular location | — |
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| Keywords | — |
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Druggability
Target tractability assessment (Open Targets + pocket analysis). No approved drug
| Druggability tier | MEDIUM |
|---|
| Druggability score | — |
|---|
| Pocket score | — |
|---|
| Max clinical phase | — |
|---|
Disease associations (300)
Diseases linked to this target (Open Targets).
- blood protein measurement · score 0.34
- neoplasm · score 0.09
- hypertrophic cardiomyopathy · score 0.08
- common variable immunodeficiency · score 0.07
- Arrhythmogenic right ventricular dysplasia · score 0.07
- neutrophil immunodeficiency syndrome · score 0.07
- Brugada syndrome · score 0.07
- Romano-Ward syndrome · score 0.07
- severe combined immunodeficiency due to CARD11 deficiency · score 0.07
- isolated agammaglobulinemia · score 0.06
3D Structure (1)
Experimental (PDB) and predicted (AlphaFold) structures for this protein.
| Structure | Source | Method | Mean pLDDT | Resolution (Å) |
|---|
| AF-Q6ISS4-F1 | alphafold | PREDICTED | 85.18 | — |
Amino-acid sequence (152 residues)
MSPHLTALLG LVLCLAQTIH TQEGALPRPS ISAEPGTVIS PGSHVTFMCR GPVGVQTFRL EREDRAKYKD SYNVFRLGPS ESEARFHIDS VSEGNAGLYR CLYYKPPGWS EHSDFLELLV KESSGGPDSP DTEPGSSAGT VPGTEASGFD AP
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