Growth/differentiation factor 6 (GDF6)

About Growth/differentiation factor 6

Growth/differentiation factor 6 (GDF6) is a protein from Homo sapiens identified by UniProt accession Q6KF10, 455 residues long. MolForge cross-references it against 0 known binders and 212 disease associations.

Target properties

Protein name	Growth/differentiation factor 6
UniProt accession	Q6KF10
Gene	GDF6
Organism	Homo sapiens
Length	455 residues
Molecular weight	—
EC numbers	—
Target class	UNCLASSIFIED
Subcellular location	—
Keywords	—

Druggability

Target tractability assessment (Open Targets + pocket analysis). No approved drug

Druggability tier	MEDIUM
Druggability score	—
Pocket score	—
Max clinical phase	—

Disease associations (212)

Diseases linked to this target (Open Targets).

Klippel-Feil syndrome 1, autosomal dominant · score 0.79
isolated microphthalmia 4 · score 0.74
Leber congenital amaurosis 17 · score 0.69
Isolated anophthalmia - microphthalmia · score 0.68
microphthalmia · score 0.58
multiple synostoses syndrome · score 0.47
congenital hydronephrosis · score 0.44
congenital anomaly of kidney and urinary tract · score 0.44
microphthalmia, isolated, with coloboma · score 0.41
Leber congenital amaurosis · score 0.37

3D Structure (1)

Experimental (PDB) and predicted (AlphaFold) structures for this protein.

Structure	Source	Method	Mean pLDDT	Resolution (Å)
AF-Q6KF10-F1	alphafold	PREDICTED	70.09	—

Amino-acid sequence (455 residues)

MDTPRVLLSA VFLISFLWDL PGFQQASISS SSSSAELGST KGMRSRKEGK MQRAPRDSDA GREGQEPQPR PQDEPRAQQP RAQEPPGRGP RVVPHEYMLS IYRTYSIAEK LGINASFFQS SKSANTITSF VDRGLDDLSH TPLRRQKYLF DVSMLSDKEE LVGAELRLFR QAPSAPWGPP AGPLHVQLFP CLSPLLLDAR TLDPQGAPPA GWEVFDVWQG LRHQPWKQLC LELRAAWGEL DAGEAEARAR GPQQPPPPDL RSLGFGRRVR PPQERALLVV FTRSQRKNLF AEMREQLGSA EAAGPGAGAE GSWPPPSGAP DARPWLPSPG RRRRRTAFAS RHGKRHGKKS RLRCSKKPLH VNFKELGWDD WIIAPLEYEA YHCEGVCDFP LRSHLEPTNH AIIQTLMNSM DPGSTPPSCC VPTKLTPISI LYIDAGNNVV YKQYEDMVVE SCGCR

External references

UniProt AlphaFold QuickGO RCSB PDB GeneCards