About S-adenosyl-L-methionine-dependent tRNA 4-demethylwyosine synthase TYW1B
S-adenosyl-L-methionine-dependent tRNA 4-demethylwyosine synthase TYW1B (TYW1B) is a protein
from Homo sapiens identified by UniProt accession
Q6NUM6, 668 residues long.
MolForge cross-references it against 0 known binders and
21 disease associations.
Target properties
| Protein name | S-adenosyl-L-methionine-dependent tRNA 4-demethylwyosine synthase TYW1B |
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| UniProt accession | Q6NUM6 |
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| Gene | TYW1B |
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| Organism | Homo sapiens |
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| Length | 668 residues |
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| Molecular weight | — |
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| EC numbers | — |
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| Target class | UNCLASSIFIED |
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| Subcellular location | — |
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| Keywords | — |
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Druggability
Target tractability assessment (Open Targets + pocket analysis). No approved drug
| Druggability tier | MEDIUM |
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| Druggability score | — |
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| Pocket score | — |
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| Max clinical phase | — |
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Disease associations (21)
Diseases linked to this target (Open Targets).
- self reported educational attainment · score 0.25
- mathematical ability · score 0.13
- triglyceride measurement · score 0.09
- musculoskeletal system disease · score 0.07
- connective tissue disease · score 0.07
- hemoglobin E-beta-thalassemia syndrome · score 0.05
- hemoglobin D disease · score 0.04
- Hemolytic anemia due to red cell pyruvate kinase deficiency · score 0.04
- hemoglobin E disease · score 0.03
- dominant beta-thalassemia · score 0.03
3D Structure (1)
Experimental (PDB) and predicted (AlphaFold) structures for this protein.
| Structure | Source | Method | Mean pLDDT | Resolution (Å) |
|---|
| AF-Q6NUM6-F1 | alphafold | PREDICTED | 76.24 | — |
Amino-acid sequence (668 residues)
MDPSADTWDL SSPLISLWIN RFYIYLGFAV SISLWICVQI VIEMQGFATV LAEAVTSLDL PVAIINLKEY DPDDHLIEEV TSKNVCVFLV ATYTDGLPTE SAEWFCKWLE EASIDFRFGK TYLKGMRDAV FGLGNSAYAS HFNKVGKNVD KWLWMLGVHR VMSRGEGDCD VVKSKHGSIE ANFRAWKTKF ISQLQALQKG ERKKSCGGHC KKGKCESHQH GSEEREEGSQ EQDELHHRDT KEEEPFESSS EEEFGGEDHQ SLNSIVDVED LGKIMDHVKK EKREKEQQEE KSGLFRNMGR NEDGERRAMI TPALREALTK QVDAPRERSL LQTHILWNES HRCMETTPSL ACANKCVFCW WHHNNPVGTE WLWKMDQPEM ILKEAIENHQ NMIKQFKGVP GVKAERFEEG MTVKHCALSL VGEPIMYPEI NRFLKLLHQC KISSFLVTNA QFPAEIRNLE PVTQLYVSVD ASTKDSLKKI DRPLFKDFWQ QFLDSLKALA VKQQRTVYRL MLVKAWNVDE LQAYAQLVSL GNPDFIEVKG VTYCRESSAS SLTMAHVPWH EEVVQFVREL VDLIPEYEIA CEHEHSNCLL IAHRKFKIGG EWWTWIDYNR FQELIQEYED SGGSKTFSAK DYMARTPHWA LFGANERSFD PKDTRHQRKN KSKAISGC
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