About Tectonic-3
Tectonic-3 (TCTN3) is a protein
from Homo sapiens identified by UniProt accession
Q6NUS6, 607 residues long.
MolForge cross-references it against 0 known binders and
138 disease associations.
Target properties
| Protein name | Tectonic-3 |
|---|
| UniProt accession | Q6NUS6 |
|---|
| Gene | TCTN3 |
|---|
| Organism | Homo sapiens |
|---|
| Length | 607 residues |
|---|
| Molecular weight | — |
|---|
| EC numbers | — |
|---|
| Target class | UNCLASSIFIED |
|---|
| Subcellular location | — |
|---|
| Keywords | — |
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Druggability
Target tractability assessment (Open Targets + pocket analysis). No approved drug
| Druggability tier | MEDIUM |
|---|
| Druggability score | — |
|---|
| Pocket score | — |
|---|
| Max clinical phase | — |
|---|
Disease associations (138)
Diseases linked to this target (Open Targets).
- orofaciodigital syndrome IV · score 0.78
- Joubert syndrome 18 · score 0.76
- Orofaciodigital syndrome type 4 · score 0.70
- Joubert syndrome · score 0.62
- Joubert syndrome and related disorders · score 0.47
- Joubert syndrome with orofaciodigital defect · score 0.46
- genetic disorder · score 0.41
- blood protein measurement · score 0.40
- Meckel syndrome · score 0.38
- ciliopathy · score 0.37
3D Structure (1)
Experimental (PDB) and predicted (AlphaFold) structures for this protein.
| Structure | Source | Method | Mean pLDDT | Resolution (Å) |
|---|
| AF-Q6NUS6-F1 | alphafold | PREDICTED | 71.19 | — |
Amino-acid sequence (607 residues)
MRTPQLALLQ VFFLVFPDGV RPQPSSSPSG AVPTSLELQR GTDGGTLQSP SEATATRPAV PGLPTVVPTL VTPSAPGNRT VDLFPVLPIC VCDLTPGACD INCCCDRDCY LLHPRTVFSF CLPGSVRSSS WVCVDNSVIF RSNSPFPSRV FMDSNGIRQF CVHVNNSNLN YFQKLQKVNA TNFQALAAEF GGESFTSTFQ TQSPPSFYRA GDPILTYFPK WSVISLLRQP AGVGAGGLCA ESNPAGFLES KSTTCTRFFK NLASSCTLDS ALNAASYYNF TVLKVPRSMT DPQNMEFQVP VILTSQANAP LLAGNTCQNV VSQVTYEIET NGTFGIQKVS VSLGQTNLTV EPGASLQQHF ILRFRAFQQS TAASLTSPRS GNPGYIVGKP LLALTDDISY SMTLLQSQGN GSCSVKRHEV QFGVNAISGC KLRLKKADCS HLQQEIYQTL HGRPRPEYVA IFGNADPAQK GGWTRILNRH CSISAINCTS CCLIPVSLEI QVLWAYVGLL SNPQAHVSGV RFLYQCQSIQ DSQQVTEVSL TTLVNFVDIT QKPQPPRGQP KMDWKWPFDF FPFKVAFSRG VFSQKCSVSP ILILCLLLLG VLNLETM
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