About Ribonuclease MRP subunit P64
Ribonuclease MRP subunit P64 (RMP64) is a protein
from Homo sapiens identified by UniProt accession
Q6NW34, 567 residues long.
MolForge cross-references it against 0 known binders and
14 disease associations.
Target properties
| Protein name | Ribonuclease MRP subunit P64 |
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| UniProt accession | Q6NW34 |
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| Gene | RMP64 |
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| Organism | Homo sapiens |
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| Length | 567 residues |
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| Molecular weight | — |
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| EC numbers | — |
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| Target class | UNCLASSIFIED |
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| Subcellular location | — |
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| Keywords | — |
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Druggability
Target tractability assessment (Open Targets + pocket analysis). No approved drug
| Druggability tier | MEDIUM |
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| Druggability score | — |
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| Pocket score | — |
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| Max clinical phase | — |
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Disease associations (14)
Diseases linked to this target (Open Targets).
- anauxetic dysplasia 3 · score 0.52
- anauxetic dysplasia · score 0.37
- body height · score 0.23
- BMI-adjusted waist circumference · score 0.16
- protein measurement · score 0.16
- Abnormal cerebral white matter morphology · score 0.15
- Microcephaly · score 0.15
- appendicular lean mass · score 0.05
- eosinophil count · score 0.05
- lymphocyte count · score 0.04
3D Structure (1)
Experimental (PDB) and predicted (AlphaFold) structures for this protein.
| Structure | Source | Method | Mean pLDDT | Resolution (Å) |
|---|
| AF-Q6NW34-F1 | alphafold | PREDICTED | 64.03 | — |
Amino-acid sequence (567 residues)
MMAAVPPGLE PWNRVRIPKA GNRSAVTVQN PGAALDLCIA AVIKECHLVI LSLKSQTLDA ETDVLCAVLY SNHNRMGRHK PHLALKQVEQ CLKRLKNMNL EGSIQDLFEL FSSNENQPLT TKVCVVPSQP VVELVLMKVL GACKLLLRLL DCCCKTFLLT VKHLGLQEFI ILNLVMVGLV SRLWVLYKGV LKRLILLYEP LFGLLQEVAR IQPMPYFKDF TFPSDITEFL GQPYFEAFKK KMPIAFAAKG INKLLNKLFL INEQSPRASE ETLLGISKKA KQMKINVQNN VDLGQPVKNK RVFKEESSEF DVRAFCNQLK HKATQETSFD FKCSQSRLKT TKYSSQKVIG TPHAKSFVQR FREAESFTQL SEEIQMAVVW CRSKKLKAQA IFLGNKLLKS NRLKHLEAQG TSLPKKLECI KTSICNHLLR GSGIKTSKHH LRQRRSQNKF LRRQRKPQRK LQSTLLREIQ QFSQGTRKSA TDTSAKWRLS HCTVHRTDLY PNSKQLLNSG VSMPVIQTKE KMIHENLRGI HENETDSWTV MQINKNSTSG TIKETDDIDD IFALMGV
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