Transmembrane protein 53 (TMEM53)

About Transmembrane protein 53

Transmembrane protein 53 (TMEM53) is a protein from Homo sapiens identified by UniProt accession Q6P2H8, 277 residues long. MolForge cross-references it against 0 known binders and 237 disease associations.

Target properties

Protein name	Transmembrane protein 53
UniProt accession	Q6P2H8
Gene	TMEM53
Organism	Homo sapiens
Length	277 residues
Molecular weight	—
EC numbers	—
Target class	UNCLASSIFIED
Subcellular location	—
Keywords	—

Druggability

Target tractability assessment (Open Targets + pocket analysis). No approved drug

Druggability tier	MEDIUM
Druggability score	—
Pocket score	—
Max clinical phase	—

Disease associations (237)

Diseases linked to this target (Open Targets).

craniotubular dysplasia, Ikegawa type · score 0.52
leukodystrophy, hypomyelinating, 23, with ataxia, deafness, liver dysfunction, and dilated cardiomyopathy · score 0.42
brachydactylous dwarfism, Mseleni type · score 0.10
X-linked non-syndromic intellectual disability · score 0.09
Bartter syndrome · score 0.09
SHOX-related short stature · score 0.09
heart rate response to recovery post exercise · score 0.09
heart rate response to exercise · score 0.09
chromosome 22q11.2 deletion syndrome, distal · score 0.07
Hyaluronidase deficiency · score 0.06

3D Structure (1)

Experimental (PDB) and predicted (AlphaFold) structures for this protein.

Structure	Source	Method	Mean pLDDT	Resolution (Å)
AF-Q6P2H8-F1	alphafold	PREDICTED	89.43	—

Amino-acid sequence (277 residues)

MASAELDYTI EIPDQPCWSQ KNSPSPGGKE AETRQPVVIL LGWGGCKDKN LAKYSAIYHK RGCIVIRYTA PWHMVFFSES LGIPSLRVLA QKLLELLFDY EIEKEPLLFH VFSNGGVMLY RYVLELLQTR RFCRLRVVGT IFDSAPGDSN LVGALRALAA ILERRAAMLR LLLLVAFALV VVLFHVLLAP ITALFHTHFY DRLQDAGSRW PELYLYSRAD EVVLARDIER MVEARLARRV LARSVDFVSS AHVSHLRDYP TYYTSLCVDF MRNCVRC

External references

UniProt AlphaFold QuickGO RCSB PDB GeneCards