About Serine/threonine-protein kinase Nek5
Serine/threonine-protein kinase Nek5 (NEK5) is a protein
from Homo sapiens identified by UniProt accession
Q6P3R8, 708 residues long.
MolForge cross-references it against 0 known binders and
67 disease associations.
Target properties
| Protein name | Serine/threonine-protein kinase Nek5 |
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| UniProt accession | Q6P3R8 |
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| Gene | NEK5 |
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| Organism | Homo sapiens |
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| Length | 708 residues |
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| Molecular weight | — |
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| EC numbers | — |
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| Target class | UNCLASSIFIED |
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| Subcellular location | — |
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| Keywords | — |
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Druggability
Target tractability assessment (Open Targets + pocket analysis). No approved drug
| Druggability tier | MEDIUM |
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| Druggability score | — |
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| Pocket score | — |
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| Max clinical phase | — |
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Approved drugs hitting this target (3)
DrugCentral-linked approved drugs that act on this protein.
Disease associations (67)
Diseases linked to this target (Open Targets).
- neuroinflammatory disorder · score 0.33
- Red cell distribution width · score 0.21
- deafness · score 0.12
- hearing loss, autosomal recessive · score 0.09
- deafness, aminoglycoside-induced · score 0.07
- autosomal dominant nonsyndromic hearing loss 17 · score 0.07
- autosomal dominant nonsyndromic hearing loss 7 · score 0.07
- autosomal recessive nonsyndromic hearing loss 1B · score 0.07
- autosomal dominant nonsyndromic hearing loss · score 0.07
- otosclerosis · score 0.06
3D Structure (1)
Experimental (PDB) and predicted (AlphaFold) structures for this protein.
| Structure | Source | Method | Mean pLDDT | Resolution (Å) |
|---|
| AF-Q6P3R8-F1 | alphafold | PREDICTED | 59.24 | — |
Amino-acid sequence (708 residues)
MDKYDVIKAI GQGAFGKAYL AKGKSDSKHC VIKEINFEKM PIQEKEASKK EVILLEKMKH PNIVAFFNSF QENGRLFIVM EYCDGGDLMK RINRQRGVLF SEDQILGWFV QISLGLKHIH DRKILHRDIK AQNIFLSKNG MVAKLGDFGI ARVLNNSMEL ARTCIGTPYY LSPEICQNKP YNNKTDIWSL GCVLYELCTL KHPFEGNNLQ QLVLKICQAH FAPISPGFSR ELHSLISQLF QVSPRDRPSI NSILKRPFLE NLIPKYLTPE VIQEEFSHML ICRAGAPASR HAGKVVQKCK IQKVRFQGKC PPRSRISVPI KRNAILHRNE WRPPAGAQKA RSIKMIERPK IAAVCGHYDY YYAQLDMLRR RAHKPSYHPI PQENTGVEDY GQETRHGPSP SQWPAEYLQR KFEAQQYKLK VEKQLGLRPS SAEPNYNQRQ ELRSNGEEPR FQELPFRKNE MKEQEYWKQL EEIRQQYHND MKEIRKKMGR EPEENSKISH KTYLVKKSNL PVHQDASEGE APVQMEFRSC CPGWSAMARS WLTATSASQD IEKDLKQMRL QNTKESKNPE QKYKAKKGVK FEINLDKCIS DENILQEEEA MDIPNETLTF EDGMKFKEYE CVKEHGDYTD KAFEKLHCPE AGFSTQTVAA VGNRRQWDGG APQTLLQMMA VADITSTCPT GPDSESVLSV SRQEGKTKDP YSPVLILM
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