About Thioredoxin domain-containing protein 11
Thioredoxin domain-containing protein 11 (TXNDC11) is a protein
from Homo sapiens identified by UniProt accession
Q6PKC3, 985 residues long.
MolForge cross-references it against 0 known binders and
37 disease associations.
Target properties
| Protein name | Thioredoxin domain-containing protein 11 |
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| UniProt accession | Q6PKC3 |
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| Gene | TXNDC11 |
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| Organism | Homo sapiens |
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| Length | 985 residues |
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| Molecular weight | — |
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| EC numbers | — |
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| Target class | UNCLASSIFIED |
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| Subcellular location | — |
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| Keywords | — |
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Druggability
Target tractability assessment (Open Targets + pocket analysis). No approved drug
| Druggability tier | MEDIUM |
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| Druggability score | — |
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| Pocket score | — |
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| Max clinical phase | — |
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Disease associations (37)
Diseases linked to this target (Open Targets).
- neurodegenerative disease · score 0.40
- sex hormone-binding globulin measurement · score 0.32
- rheumatoid arthritis · score 0.29
- alkaline phosphatase measurement · score 0.27
- mean corpuscular volume · score 0.26
- Red cell distribution width · score 0.24
- triglyceride measurement · score 0.22
- mean reticulocyte volume · score 0.20
- leukocyte count · score 0.18
- neutrophil count · score 0.14
3D Structure (1)
Experimental (PDB) and predicted (AlphaFold) structures for this protein.
| Structure | Source | Method | Mean pLDDT | Resolution (Å) |
|---|
| AF-Q6PKC3-F1 | alphafold | PREDICTED | 70.94 | — |
Amino-acid sequence (985 residues)
MSECGGRGGG SSSSEDAEDE GGGGGGPAGS DCLSSSPTLA TASSAGRLRR GLRGAFLMAR QRPELLCGAV ALGCALLLAL KFTCSRAKDV IIPAKPPVSF FSLRSPVLDL FQGQLDYAEY VRRDSEVVLL FFYAPWCGQS IAARAEIEQA ASRLSDQVLF VAINCWWNQG KCRKQKHFFY FPVIYLYHRS FGPIEYKGPM SAVYIEKFVR RVMKPLLYIP SQSELLDFLS NYEPGVLGYF EFSGSPQPPG YLTFFTSALH SLKKALESTS SPRALVSFTG EWHLETKIYV LDYLGTVRFG VITNKHLAKL VSLVHSGSVY LHRHFNTSLV FPREVLNYTA ENICKWALEN QETLFRWLRP HGGKSLLLNN ELKKGPALFL FIPFNPLAES HPLIDEITEV ALEYNNCHGD QVVERLLQHL RRVDAPVLES LALEVPAQLP DPPTITASPC CNTVVLPQWH SFSRTHNVCE LCVNQTSGGM KPSSVSVPQC SFFEMAAALD SFYLKEQTFY HVASDSIECS NFLTSYSPFS YYTACCRTIS RGVSGFIDSE QGVFEAPTVA FSSLEKKCEV DAPSSVPHIE ENRYLFPEVD MTSTNFTGLS CRTNKTLNIY LLDSNLFWLY AERLGAPSST QVKEFAAIVD VKEESHYILD PKQALMKLTL ESFIQNFSVL YSPLKRHLIG SGSAQFPSQH LITEVTTDTF WEVVLQKQDV LLLYYAPWCG FCPSLNHIFI QLARNLPMDT FTVARIDVSQ NDLPWEFMVD RLPTVLFFPC NRKDLSVKYP EDVPITLPNL LRFILHHSDP ASSPQNVANS PTKECLQSEA VLQRGHISHL EREIQKLRAE ISSLQRAQVQ VESQLSSARR DEHRLRQQQR ALEEQHSLLH AHSEQLQALY EQKTRELQEL ARKLQELADA SENLLTENTW LKILVATMER KLEGRDGAES LAAQREVHPK QPEPSATPQL PGSSPPPANV SATLVSERNK ENRTD
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