Ly6/PLAUR domain-containing protein 4 (LYPD4)

About Ly6/PLAUR domain-containing protein 4

Ly6/PLAUR domain-containing protein 4 (LYPD4) is a protein from Homo sapiens identified by UniProt accession Q6UWN0, 246 residues long. MolForge cross-references it against 0 known binders and 122 disease associations.

Target properties

Protein name	Ly6/PLAUR domain-containing protein 4
UniProt accession	Q6UWN0
Gene	LYPD4
Organism	Homo sapiens
Length	246 residues
Molecular weight	—
EC numbers	—
Target class	UNCLASSIFIED
Subcellular location	—
Keywords	—

Druggability

Target tractability assessment (Open Targets + pocket analysis). No approved drug

Druggability tier	MEDIUM
Druggability score	—
Pocket score	—
Max clinical phase	—

Disease associations (122)

Diseases linked to this target (Open Targets).

azoospermia · score 0.08
male infertility with teratozoospermia due to single gene mutation · score 0.07
Rare genetic female infertility · score 0.07
gonorrhea · score 0.07
Female infertility due to fertilization defect · score 0.07
partial chromosome Y deletion · score 0.06
spermatogenic failure 3 · score 0.06
spermatogenic failure 55 · score 0.06
female infertility due to oocyte meiotic arrest · score 0.06
spermatogenic failure 7 · score 0.06

3D Structure (1)

Experimental (PDB) and predicted (AlphaFold) structures for this protein.

Structure	Source	Method	Mean pLDDT	Resolution (Å)
AF-Q6UWN0-F1	alphafold	PREDICTED	84.72	—

Amino-acid sequence (246 residues)

MGPQHLRLVQ LFCLLGAIST LPRAGALLCY EATASRFRAV AFHNWKWLLM RNMVCKLQEG CEETLVFIET GTARGVVGFK GCSSSSSYPA QISYLVSPPG VSIASYSRVC RSYLCNNLTN LEPFVKLKAS TPKSITSASC SCPTCVGEHM KDCLPNFVTT NSCPLAASTC YSSTLKFQAG FLNTTFLLMG CAREHNQLLA DFHHIGSIKV TEVLNILEKS QIVGAASSRQ DPAWGVVLGL LFAFRD

External references

UniProt AlphaFold QuickGO RCSB PDB GeneCards