Protein disulfide isomerase CRELD2 (CRELD2)

About Protein disulfide isomerase CRELD2

Protein disulfide isomerase CRELD2 (CRELD2) is a protein from Homo sapiens identified by UniProt accession Q6UXH1, 353 residues long. MolForge cross-references it against 0 known binders and 131 disease associations.

Target properties

Protein name	Protein disulfide isomerase CRELD2
UniProt accession	Q6UXH1
Gene	CRELD2
Organism	Homo sapiens
Length	353 residues
Molecular weight	—
EC numbers	—
Target class	UNCLASSIFIED
Subcellular location	—
Keywords	—

Druggability

Target tractability assessment (Open Targets + pocket analysis). No approved drug

Druggability tier	MEDIUM
Druggability score	—
Pocket score	—
Max clinical phase	—

Disease associations (131)

Diseases linked to this target (Open Targets).

neurodegenerative disease · score 0.39
sex hormone-binding globulin measurement · score 0.29
acne · score 0.20
platelet count · score 0.20
mean platelet volume · score 0.18
serum albumin measurement · score 0.17
ALG12-congenital disorder of glycosylation · score 0.16
heel bone mineral density · score 0.16
DNA methylation · score 0.12
platelet component distribution width · score 0.11

3D Structure (1)

Experimental (PDB) and predicted (AlphaFold) structures for this protein.

Structure	Source	Method	Mean pLDDT	Resolution (Å)
AF-Q6UXH1-F1	alphafold	PREDICTED	87.65	—

Amino-acid sequence (353 residues)

MRLPRRAALG LLPLLLLLPP APEAAKKPTP CHRCRGLVDK FNQGMVDTAK KNFGGGNTAW EEKTLSKYES SEIRLLEILE GLCESSDFEC NQMLEAQEEH LEAWWLQLKS EYPDLFEWFC VKTLKVCCSP GTYGPDCLAC QGGSQRPCSG NGHCSGDGSR QGDGSCRCHM GYQGPLCTDC MDGYFSSLRN ETHSICTACD ESCKTCSGLT NRDCGECEVG WVLDEGACVD VDECAAEPPP CSAAQFCKNA NGSYTCEECD SSCVGCTGEG PGNCKECISG YAREHGQCAD VDECSLAEKT CVRKNENCYN TPGSYVCVCP DGFEETEDAC VPPAEAEATE GESPTQLPSR EDL

External references

UniProt AlphaFold QuickGO RCSB PDB GeneCards