About Nephronectin
Nephronectin (NPNT) is a protein
from Homo sapiens identified by UniProt accession
Q6UXI9, 565 residues long.
MolForge cross-references it against 0 known binders and
140 disease associations.
Target properties
| Protein name | Nephronectin |
|---|
| UniProt accession | Q6UXI9 |
|---|
| Gene | NPNT |
|---|
| Organism | Homo sapiens |
|---|
| Length | 565 residues |
|---|
| Molecular weight | — |
|---|
| EC numbers | — |
|---|
| Target class | UNCLASSIFIED |
|---|
| Subcellular location | — |
|---|
| Keywords | — |
|---|
Druggability
Target tractability assessment (Open Targets + pocket analysis). No approved drug
| Druggability tier | MEDIUM |
|---|
| Druggability score | — |
|---|
| Pocket score | — |
|---|
| Max clinical phase | — |
|---|
Disease associations (140)
Diseases linked to this target (Open Targets).
- systolic blood pressure · score 0.50
- forced expiratory volume · score 0.48
- diastolic blood pressure · score 0.47
- hypertension · score 0.47
- FEV/FVC ratio · score 0.46
- chronic obstructive pulmonary disease · score 0.45
- cardiovascular disease · score 0.43
- vital capacity · score 0.42
- Agents acting on the renin-angiotensin system use measurement · score 0.40
- asthma · score 0.40
3D Structure (1)
Experimental (PDB) and predicted (AlphaFold) structures for this protein.
| Structure | Source | Method | Mean pLDDT | Resolution (Å) |
|---|
| AF-Q6UXI9-F1 | alphafold | PREDICTED | 67.20 | — |
Amino-acid sequence (565 residues)
MDFLLALVLV SSLYLQAAAE FDGRWPRQIV SSIGLCRYGG RIDCCWGWAR QSWGQCQPVC QPRCKHGECI GPNKCKCHPG YAGKTCNQDL NECGLKPRPC KHRCMNTYGS YKCYCLNGYM LMPDGSCSSA LTCSMANCQY GCDVVKGQIR CQCPSPGLQL APDGRTCVDV DECATGRASC PRFRQCVNTF GSYICKCHKG FDLMYIGGKY QCHDIDECSL GQYQCSSFAR CYNIRGSYKC KCKEGYQGDG LTCVYIPKVM IEPSGPIHVP KGNGTILKGD TGNNNWIPDV GSTWWPPKTP YIPPIITNRP TSKPTTRPTP KPTPIPTPPP PPPLPTELRT PLPPTTPERP TTGLTTIAPA ASTPPGGITV DNRVQTDPQK PRGDVFIPRQ PSNDLFEIFE IERGVSADDE AKDDPGVLVH SCNFDHGLCG WIREKDNDLH WEPIRDPAGG QYLTVSAAKA PGGKAARLVL PLGRLMHSGD LCLSFRHKVT GLHSGTLQVF VRKHGAHGAA LWGRNGGHGW RQTQITLRGA DIKSVVFKGE KRRGHTGEIG LDDVSLKKGH CSEER
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