About BAR/IMD domain-containing adapter protein 2-like 2
BAR/IMD domain-containing adapter protein 2-like 2 (BAIAP2L2) is a protein
from Homo sapiens identified by UniProt accession
Q6UXY1, 529 residues long.
MolForge cross-references it against 0 known binders and
91 disease associations.
Target properties
| Protein name | BAR/IMD domain-containing adapter protein 2-like 2 |
|---|
| UniProt accession | Q6UXY1 |
|---|
| Gene | BAIAP2L2 |
|---|
| Organism | Homo sapiens |
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| Length | 529 residues |
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| Molecular weight | — |
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| EC numbers | — |
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| Target class | UNCLASSIFIED |
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| Subcellular location | — |
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| Keywords | — |
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Druggability
Target tractability assessment (Open Targets + pocket analysis). No approved drug
| Druggability tier | MEDIUM |
|---|
| Druggability score | — |
|---|
| Pocket score | — |
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| Max clinical phase | — |
|---|
Disease associations (91)
Diseases linked to this target (Open Targets).
- white matter microstructure measurement · score 0.31
- neurodegenerative disease · score 0.27
- hearing loss · score 0.17
- diet measurement · score 0.16
- PLA2G6-associated neurodegeneration · score 0.15
- age-related hearing impairment · score 0.14
- lean body mass · score 0.12
- body weight · score 0.09
- central nervous system cancer · score 0.09
- glioblastoma multiforme · score 0.09
3D Structure (1)
Experimental (PDB) and predicted (AlphaFold) structures for this protein.
| Structure | Source | Method | Mean pLDDT | Resolution (Å) |
|---|
| AF-Q6UXY1-F1 | alphafold | PREDICTED | 69.88 | — |
Amino-acid sequence (529 residues)
MAPEMDQFYR STMAIYKSIM EQFNPALENL VYLGNNYLRA FHALSEAAEV YFSAIQKIGE RALQSPTSQI LGEILVQMSD TQRHLNSDLE VVVQTFHGGL LQHMEKNTKL DMQFIKDSRQ HYELEYRHRA ANLEKCMSEL WRMERKRDKN VREMKESVNR LHAQMQAFVS ESQRAAELEE KRRYRFLAEK HLLLSNTFLQ FFGRARGMLQ NRVLLWKEQS EASRSPSRAH SPGLLGPALG PPYPSGRLTP TCLDMPPRPL GEFSSPRSRH GSGSYGTEPD ARPASQLEPD RRSLPRTPSA SSLYSGSAQS SRSNSFGERP GGGGGARRVR ALVSHSEGAN HTLLRFSAGD VVEVLVPEAQ NGWLYGKLEG SSASGWFPEA YVKALEEGPV NPMTPVTPMT SMTSMSPMTP MNPGNELPSR SYPLRGSHSL DDLLDRPGNS IAPSEYWDGQ SRSRTPSRVP SRAPSPAPPP LPSSRRSSMG STAVATDVKK LMSSEQYPPQ ELFPRGTNPF ATVKLRPTIT NDRSAPLIR
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