About Cyclin-I2
Cyclin-I2 (CCNI2) is a protein
from Homo sapiens identified by UniProt accession
Q6ZMN8, 369 residues long.
MolForge cross-references it against 0 known binders and
18 disease associations.
Target properties
| Protein name | Cyclin-I2 |
|---|
| UniProt accession | Q6ZMN8 |
|---|
| Gene | CCNI2 |
|---|
| Organism | Homo sapiens |
|---|
| Length | 369 residues |
|---|
| Molecular weight | — |
|---|
| EC numbers | — |
|---|
| Target class | UNCLASSIFIED |
|---|
| Subcellular location | — |
|---|
| Keywords | — |
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Druggability
Target tractability assessment (Open Targets + pocket analysis). No approved drug
| Druggability tier | MEDIUM |
|---|
| Druggability score | — |
|---|
| Pocket score | — |
|---|
| Max clinical phase | — |
|---|
Disease associations (18)
Diseases linked to this target (Open Targets).
- body height · score 0.16
- childhood onset asthma · score 0.06
- respiratory system disease · score 0.06
- neoplasm · score 0.06
- atopic eczema · score 0.05
- lean body mass · score 0.05
- eosinophil count · score 0.05
- Barrett's esophagus · score 0.05
- pancreatic adenocarcinoma · score 0.04
- esophageal adenocarcinoma · score 0.04
3D Structure (1)
Experimental (PDB) and predicted (AlphaFold) structures for this protein.
| Structure | Source | Method | Mean pLDDT | Resolution (Å) |
|---|
| AF-Q6ZMN8-F1 | alphafold | PREDICTED | 74.08 | — |
Amino-acid sequence (369 residues)
MASGAQLPPQ PSSSEVSAVQ SPGGRPGAGL EETALGVPLP PSPGEAPLPR SNRSRCPGTR QPGAASLHAA SAAVPVRPRR GTAPAGKTAD AVPAAAPEQA PRPAPQSRKP RNLEGDLDER RLLCHLQLAQ DREARLWRGG KPQDEICDAF EEVVLWLLRL QNTFYFSQST FNLALTIFGR LLISVKVKEK YLHCATITSL RLAAKVNEEE EFIPQVKDFT KHYGSDYSPN ELLRMELAIL DRLHWDLYIG TPLDFLTIFH ALVVLSWPHV LELLPQRNPS LHVASLTRQL QHCMAGHQLL QFKGSTLALV IITLELERLM PGWCAPISDL LKKAQVGDMQ YSCCKELVMQ QLRSLQSSSC TDNFVSPAN
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