About SPOC domain-containing protein 1
SPOC domain-containing protein 1 (SPOCD1) is a protein
from Homo sapiens identified by UniProt accession
Q6ZMY3, 1216 residues long.
MolForge cross-references it against 0 known binders and
139 disease associations.
Target properties
| Protein name | SPOC domain-containing protein 1 |
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| UniProt accession | Q6ZMY3 |
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| Gene | SPOCD1 |
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| Organism | Homo sapiens |
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| Length | 1216 residues |
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| Molecular weight | — |
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| EC numbers | — |
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| Target class | UNCLASSIFIED |
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| Subcellular location | — |
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| Keywords | — |
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Druggability
Target tractability assessment (Open Targets + pocket analysis). No approved drug
| Druggability tier | MEDIUM |
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| Druggability score | — |
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| Pocket score | — |
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| Max clinical phase | — |
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Disease associations (139)
Diseases linked to this target (Open Targets).
- reticulocyte count · score 0.40
- male infertility with azoospermia or oligozoospermia due to single gene mutation · score 0.38
- reticulocyte measurement · score 0.37
- testosterone measurement · score 0.27
- BMI-adjusted hip circumference · score 0.25
- neurodegenerative disease · score 0.21
- BMI-adjusted waist circumference · score 0.14
- azoospermia · score 0.09
- lymphocyte count · score 0.08
- esophageal squamous cell carcinoma · score 0.08
3D Structure (1)
Experimental (PDB) and predicted (AlphaFold) structures for this protein.
| Structure | Source | Method | Mean pLDDT | Resolution (Å) |
|---|
| AF-Q6ZMY3-F1 | alphafold | PREDICTED | 47.03 | — |
Amino-acid sequence (1216 residues)
MSQAGDVEGP STGDPVLSPQ HNCELLQNME GASSMPGLSP DGPGASSGPG VRAGSRRKIP RKEALRGGSS RAAGAAEVRP GVLELLAVVQ SRGSMLAPGL HMQLPSVPTQ GRALTSKRLQ VSLCDILDDS CPRKLCSRSA GLPERALACR ERLAGVEEVS CLRPREARDG GMSSPGCDRR SPTLSKEEPP GRPLTSSPDP VPVRVRKKWR RQGAHSECEE GAGDFLWLDQ SPRGDNLLSV GDPPQVADLE SLGGPCRPPS PKDTGSGPGE PGGSGAGCAS GTEKFGYLPA TGDGPQPGSP CGPVGFPVPS GGESLSSAAQ APPQSAALCL GASAQASAEQ QEAVCVVRTG SDEGQAPAQD QEELEAKAQP ASRGRLEQGL AAPADTCASS REPLGGLSSS LDTEASRACS GPFMEQRRSK GTKNLKKGPV PCAQDRGTDR SSDNSHQDRP EEPSPGGCPR LEEVKIPHGV KLVCYLGSGP VIQLLGAISH GQAGGQLPPK LEVLEDLMEV SSPSPAQRLR RKKRPMVQGP AGCQVFQPSP SGGTAGDPGG LSDPFYPPRS GSLALGDPSS DPACSQSGPM EAEEDSLPEQ PEDSAQLQQE KPSLYIGVRG TVVRSMQEVL WTRLRELPDP VLSEEVVEGI AAGIEAALWD LTQGTNGRYK TKYRSLLFNL RDPRNLDLFL KVVHGDVTPY DLVRMSSMQL APQELARWRD QEEKRGLNII EQQQKEPCRL PASKMTHKGE VEIQRDMDQT LTLEDLVGPQ MFMDCSPQAL PIASEDTTGQ HDHHFLDPNC HICKDWEPSN ELLGSFEAAK SCGDNIFQKA LSQTPMPAPE MPKTRELSPT EPQDRVPPSG LHVPAAPTKA LPCLPPWEGV LDMFSIKRFR ARAQLVSGHS CRLVQALPTV IRSAGCIPSN IVWDLLASIC PAKAKDVCVV RLCPHGARDT QNCRLLYSYL NDRQRHGLAS VEHMGMVLLP LPAFQPLPTR LRPLGGPGLW ALPVSPLLSP GLEVTHSSLL LAVLLPKEGL PDTAGSSPWL GKVQKMVSFN SKVEKRYYQP DDRRPNVPLK GTPPPGGAWQ QSQGRGSIAP RGISAWQRPP RGRGRLWPEP ENWQHPGRGQ WPPEPGLRQS QHPYSVAPAG HGFGRGQHFH RDSCPHQALL RHLESLATMS HQLQALLCPQ TKSSIPRPLQ RLSSALAAPE PPGPARDSSL GPTDEAGSEC PFPRKA
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