Rho GTPase-activating protein 36 (ARHGAP36)

About Rho GTPase-activating protein 36

Rho GTPase-activating protein 36 (ARHGAP36) is a protein from Homo sapiens identified by UniProt accession Q6ZRI8, 547 residues long. MolForge cross-references it against 0 known binders and 38 disease associations.

Target properties

Protein name	Rho GTPase-activating protein 36
UniProt accession	Q6ZRI8
Gene	ARHGAP36
Organism	Homo sapiens
Length	547 residues
Molecular weight	—
EC numbers	—
Target class	UNCLASSIFIED
Subcellular location	—
Keywords	—

Druggability

Target tractability assessment (Open Targets + pocket analysis). No approved drug

Druggability tier	MEDIUM
Druggability score	—
Pocket score	—
Max clinical phase	—

Disease associations (38)

Diseases linked to this target (Open Targets).

Bazex-Dupre-Christol syndrome · score 0.19
Bazex-Dupré-Christol syndrome · score 0.19
pituitary cancer · score 0.05
platelet count · score 0.02
age at menarche · score 0.02
breast carcinoma · score 0.02
age at voice drop · score 0.02
sarcopenia · score 0.02
papillary thyroid carcinoma · score 0.01
acute quadriplegic myopathy · score 0.01

3D Structure (1)

Experimental (PDB) and predicted (AlphaFold) structures for this protein.

Structure	Source	Method	Mean pLDDT	Resolution (Å)
AF-Q6ZRI8-F1	alphafold	PREDICTED	68.00	—

Amino-acid sequence (547 residues)

MGGCIPFLKA ARALCPRIMP PLLLLSAFIF LVSVLGGAPG HNPDRRTKMV SIHSLSELER LKLQETAYHE LVARHFLSEF KPDRALPIDR PNTLDKWFLI LRGQQRAVSH KTFGISLEEV LVNEFTRRKH LELTATMQVE EATGQAAGRR RGNVVRRVFG RIRRFFSRRR NEPTLPREFT RRGRRGAVSV DSLAELEDGA LLLQTLQLSK ISFPIGQRLL GSKRKMSLNP IAKQIPQVVE ACCQFIEKHG LSAVGIFTLE YSVQRVRQLR EEFDQGLDVV LDDNQNVHDV AALLKEFFRD MKDSLLPDDL YMSFLLTATL KPQDQLSALQ LLVYLMPPCH SDTLERLLKA LHKITENCED SIGIDGQLVP GNRMTSTNLA LVFGSALLKK GKFGKRESRK TKLGIDHYVA SVNVVRAMID NWDVLFQVPP HIQRQVAKRV WKSSPEALDF IRRRNLRKIQ SARIKMEEDA LLSDPVETSA EARAAVLAQS KPSDEGSSEE PAVPSGTARS HDDEEGAGNP PIPEQDRPLL RVPREKEAKT GVSYFFP

External references

UniProt AlphaFold QuickGO RCSB PDB GeneCards