About Coiled-coil domain-containing protein 149
Coiled-coil domain-containing protein 149 (CCDC149) is a protein
from Homo sapiens identified by UniProt accession
Q6ZUS6, 474 residues long.
MolForge cross-references it against 0 known binders and
9 disease associations.
Target properties
| Protein name | Coiled-coil domain-containing protein 149 |
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| UniProt accession | Q6ZUS6 |
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| Gene | CCDC149 |
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| Organism | Homo sapiens |
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| Length | 474 residues |
|---|
| Molecular weight | — |
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| EC numbers | — |
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| Target class | UNCLASSIFIED |
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| Subcellular location | — |
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| Keywords | — |
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Druggability
Target tractability assessment (Open Targets + pocket analysis). No approved drug
| Druggability tier | MEDIUM |
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| Druggability score | — |
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| Pocket score | — |
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| Max clinical phase | — |
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Disease associations (9)
Diseases linked to this target (Open Targets).
- Cough · score 0.26
- blood protein measurement · score 0.08
- appendicitis · score 0.05
- creatinine measurement · score 0.04
- gut microbiome measurement · score 0.02
- esophageal squamous cell carcinoma · score 0.01
- visceral Leishmaniasis · score 0.01
- thyroid carcinoma · score 0.00
- Sjogren syndrome · score 0.00
3D Structure (1)
Experimental (PDB) and predicted (AlphaFold) structures for this protein.
| Structure | Source | Method | Mean pLDDT | Resolution (Å) |
|---|
| AF-Q6ZUS6-F1 | alphafold | PREDICTED | 68.17 | — |
Amino-acid sequence (474 residues)
MANQLRERHQ SLKKKYRELI DGDPSLPPEK RKQANLAQLL RDSQDRNKHL GEEIKELQQR LGEVQGDNKL LRMTIAKQRL GDEAIGVRHF AAHEREDLVQ QLERAKEQIE SLEHDLQASV DELQDVKEER SSYQDKVERL NQELNHILSG HENRIIDVDA LCMENRYLQE RLKQLHEEVN LLKSNIAKYK NALERRKNSK GQGKSSSSAL TGVLSAKQVQ DLLSEDHGCS LPATPQSISD LKSLATALLE TIHEKNMVIQ HQRQTNKILG NRVAELEKKL RTLEVSGLWS LPGGKDTILF SDPTLPSGQR SRSPLLKFVE QPTENKADPK DGEAQKQEED ESCAAAEALT APEDAGRPAV NSPANQSRGN QCKLFHPSLP QLPSEEEVNS LGREIIKLTK EQAAAELEEV RRESPIEGQR SETGPAPPGL AIQGELPKSH LDSFEASRPA AKASTPEDGK GIPEGGGMRS TVKT
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