About Serine/threonine-protein kinase MARK2
Serine/threonine-protein kinase MARK2 (MARK2) is a protein
from Homo sapiens identified by UniProt accession
Q7KZI7, 788 residues long.
MolForge cross-references it against 0 known binders and
528 disease associations.
Target properties
| Protein name | Serine/threonine-protein kinase MARK2 |
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| UniProt accession | Q7KZI7 |
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| Gene | MARK2 |
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| Organism | Homo sapiens |
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| Length | 788 residues |
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| Molecular weight | — |
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| EC numbers | — |
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| Target class | UNCLASSIFIED |
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| Subcellular location | — |
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| Keywords | — |
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Druggability
Target tractability assessment (Open Targets + pocket analysis). No approved drug
| Druggability tier | MEDIUM |
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| Druggability score | — |
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| Pocket score | — |
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| Max clinical phase | — |
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Approved drugs hitting this target (13)
DrugCentral-linked approved drugs that act on this protein.
Disease associations (528)
Diseases linked to this target (Open Targets).
- neurodegenerative disease · score 0.37
- pancreatic adenocarcinoma · score 0.19
- autism spectrum disorder · score 0.14
- attention deficit hyperactivity disorder · score 0.13
- obsessive-compulsive disorder · score 0.13
- anxiety · score 0.12
- Delayed speech and language development · score 0.12
- dyslexia · score 0.12
- Seizure · score 0.12
- bipolar disorder · score 0.10
3D Structure (1)
Experimental (PDB) and predicted (AlphaFold) structures for this protein.
| Structure | Source | Method | Mean pLDDT | Resolution (Å) |
|---|
| AF-Q7KZI7-F1 | alphafold | PREDICTED | 67.12 | — |
Amino-acid sequence (788 residues)
MSSARTPLPT LNERDTEQPT LGHLDSKPSS KSNMIRGRNS ATSADEQPHI GNYRLLKTIG KGNFAKVKLA RHILTGKEVA VKIIDKTQLN SSSLQKLFRE VRIMKVLNHP NIVKLFEVIE TEKTLYLVME YASGGEVFDY LVAHGRMKEK EARAKFRQIV SAVQYCHQKF IVHRDLKAEN LLLDADMNIK IADFGFSNEF TFGNKLDTFC GSPPYAAPEL FQGKKYDGPE VDVWSLGVIL YTLVSGSLPF DGQNLKELRE RVLRGKYRIP FYMSTDCENL LKKFLILNPS KRGTLEQIMK DRWMNVGHED DELKPYVEPL PDYKDPRRTE LMVSMGYTRE EIQDSLVGQR YNEVMATYLL LGYKSSELEG DTITLKPRPS ADLTNSSAPS PSHKVQRSVS ANPKQRRFSD QAAGPAIPTS NSYSKKTQSN NAENKRPEED RESGRKASST AKVPASPLPG LERKKTTPTP STNSVLSTST NRSRNSPLLE RASLGQASIQ NGKDSLTMPG SRASTASASA AVSAARPRQH QKSMSASVHP NKASGLPPTE SNCEVPRPST APQRVPVASP SAHNISSSGG APDRTNFPRG VSSRSTFHAG QLRQVRDQQN LPYGVTPASP SGHSQGRRGA SGSIFSKFTS KFVRRNLSFR FARRNLNEPE SKDRVETLRP HVVGSGGNDK EKEEFREAKP RSLRFTWSMK TTSSMEPNEM MREIRKVLDA NSCQSELHEK YMLLCMHGTP GHEDFVQWEM EVCKLPRLSL NGVRFKRISG TSMAFKNIAS KIANELKL
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