About Vacuolar fusion protein MON1 homolog B
Vacuolar fusion protein MON1 homolog B (MON1B) is a protein
from Homo sapiens identified by UniProt accession
Q7L1V2, 547 residues long.
MolForge cross-references it against 0 known binders and
76 disease associations.
Target properties
| Protein name | Vacuolar fusion protein MON1 homolog B |
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| UniProt accession | Q7L1V2 |
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| Gene | MON1B |
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| Organism | Homo sapiens |
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| Length | 547 residues |
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| Molecular weight | — |
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| EC numbers | — |
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| Target class | UNCLASSIFIED |
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| Subcellular location | — |
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| Keywords | — |
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Druggability
Target tractability assessment (Open Targets + pocket analysis). No approved drug
| Druggability tier | MEDIUM |
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| Druggability score | — |
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| Pocket score | — |
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| Max clinical phase | — |
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Disease associations (76)
Diseases linked to this target (Open Targets).
- neurodegenerative disease · score 0.39
- neuroticism measurement · score 0.27
- feeling "fed-up" measurement · score 0.26
- risky sexual behaviour measurement · score 0.26
- wellbeing measurement · score 0.25
- depressive symptom measurement · score 0.25
- insomnia measurement · score 0.25
- body mass index · score 0.23
- body weight · score 0.22
- aspartate aminotransferase measurement · score 0.21
3D Structure (1)
Experimental (PDB) and predicted (AlphaFold) structures for this protein.
| Structure | Source | Method | Mean pLDDT | Resolution (Å) |
|---|
| AF-Q7L1V2-F1 | alphafold | PREDICTED | 77.72 | — |
Amino-acid sequence (547 residues)
MEVGGDTAAP APGGAEDLED TQFPSEEARE GGGVHAVPPD PEDEGLEETG SKDKDQPPSP SPPPQSEALS STSRLWSPAA PENSPTCSPE SSSGGQGGDP SDEEWRSQRK HVFVLSEAGK PIYSRYGSVE ALSATMGVMT ALVSFVQSAG DAIRAIYAED HKLVFLQQGP LLLVAMSRTS QSAAQLRGEL LAVHAQIVST LTRASVARIF AHKQNYDLRR LLAGSERTLD RLLDSMEQDP GALLLGAVRC VPLARPLRDA LGALLRRCTA PGLALSVLAV GGRLITAAQE RNVLAECRLD PADLQLLLDW VGAPAFAAGE AWAPVCLPRF NPDGFFYAYV ARLDAMPVCL LLLGTQREAF HAMAACRRLV EDGMHALGAM RALGEAASFS NASSASAPAY SVQAVGAPGL RHFLYKPLDI PDHHRQLPQF TSPELEAPYS REEERQRLSD LYHRLHARLH STSRPLRLIY HVAEKETLLA WVTSKFELYT CLSPLVTKAG AILVVTKLLR WVKKEEDRLF IRYPPKYSTP PATSTDQAAH NGLFTGL
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